After a bunch of tests, I found the issue was caused by the "Moreheap" plugin, it might crash the game randomly but some heavy-loaded locations such as Maar Gan and Ghostgate will crashed always. Search forums. It is basically a modification that adds mature content to the game such as sex and pregnancy. Joined May 14, Skyrim might catch up but it seems it just doesn't have the amazing minds that worked on modding Oblivion behind it.
nest...