ph partition theory pdf
A guide to the lipophilic nature of a drug is its partition coefficient between a fat like solvent and water or an aqueous buffer. Solid Dosage Forms Document 4 pages. Compartment Modelling Document 46 pages. J and Brodie B. For a simple acid or base, the inflection point of the pHabsorption curve should occur at a pH equal to the pka of the drug.
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