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CİLT: 1
EDİTÖRLER Ç E V İR İ EDİTÖRÜ

EUGENE 3RAUNWALD, :.,o, MD(Hon), ScD(Hon) Prof.Dr. YAHYA SAGLIKER

Distinguished Hersey Professor of Medicine, ISURAT, Uluslararası Üremik Araştırmalar ve Toksisite Dem.Seçilmiş
Başkanı
Faculty Dean for Academic Programs at Brigham and
IFKF, Uluslararası Böbrek Vakıfları Federasyonu Bir Önceki Genel
Women's Hospital and Massachusetts General
Sekreteri
Hospital, Harvard Medical School; Vice-President for
Ulusal Böbrek Vakfı Kurucu Başkanı
Academic Programs, Partners Healthcare Systems,
Hipertansiyon Demeği Kurucu Başkanı
Boston
Çukurova Üniversitesi Tıp Fakültesi
Nefroloji-Hipertansiyon Bilim Dalı Öğretim Üyesi
Adana, Türkiye
ANTHONY S. FAUCI, MD ScD(Hon)
Chief, Laboratory of Immunoregulation; Director,
National Institute of Allergy and Infectious Diseases, ÇEVİRİ EDİTÖR YARDIMCILARI
National Institutes of Health, Bethesda
Prof Dr. YAKUP SARICA
Çukurova Üniversitesi Tıp Fakültesi
Nöroloji Ana Bilim Dalı Öğretim Üyesi-Adana, Türkiye
DENNIS L. KASPER, mo ma{Hoo)

William ellery Channing Professor of Medicine,

Professor ofMicrobiology and Molecular Genetics, Yrd.Doç.Dr, TAMER C.İNAİ.
Executive Dean for Academic Programs, Harvard Çukurova Üniversitesi Tıp Fakültesi
Medical School; Director, Channing Laboratory, Biyokimya Ana Bilim Dalı Öğretim Üyesi-Adana, Türkiye
Department of Medicine, Brigham and Women's
Hospital, Boston Yrd.Doç.Dr,ABD V LLAH CANATAROĞLU
Çukurova Üniversitesi Tıp Fakültesi
Romatoloji-İmmünoloji Bilim Dalı Öğretim Üyesi
STEPHEN L. HAUSER, md Adana, Türkiye
Betty Anker Fife Professor and Chairman,
Department of Neurology, University of California San Yrd.Doç.Dr. .BİROL GÜVENÇ
Francisco, Çukurova Üniversitesi Tıp Fakültesi
Hematoloji Bilim Dalı Öğretim Üyesi-Adana, Türkiye

OAN L. LONGO, mo

Scientific Director, National Institute on Aging, UVJOr. MEHMET HOROZ

Harran Üniversitesi Tıp Fakültesi
National Institutes of Health, Bethesda and Baltimore
Nefroloji B.D. Öğretim Görevlisi, Şanlıurfa, Türkiye

J. L W h Y M ^ e s o t i .10 , MO • * »’ L .S A Ğ U K F R O /A ' \YNAK

Irving S. Cutter Professor and Chairman, Sağlıker Nefroloji-Hipertansiyon Ünitesi Sorumlu Hekimi
Department of Medicine, Northwestern University Ulusal Böbrek Vakfı Kurucu Üyesi
Medical School; Physician-in-Chief, Northwestern Hipertansiyon Demeği Kumcu Üyesi
Memorial Hospital, Chicago Kuvayımilliye Dergisi Sağlık Köşesi Yazan, Adana, Türkiye

2004
 İÇİNDEKİLER

Katkıda bulunanlar 14. Karın Ağrısı 67

Önsöz William Silen
Mert Umut Özkaynak, Yahya Sağlıker Uğur Güney Ergün, Nafiz Bozdemir

Bölüm Bir 15. Başağrısı,Migren ve küme Tipi Başağrısı 70

K LİN İK T IB B A G İRİŞ Neil H. Raskin, Stephen J. Peroutka
Kürşat Özşahin, Yahya Sağlıker

1. Tıbbı Uygulama 1 16. Sırt ve Boyun Ağrısı 79

Editörler
John W. Engstrom
Pırıl Sağlıker Özkaynak, Yahya Sağlıker
Mustafa Aktekin
2. Klinik Tıpta Etik Konular 5
Bernard Lo
K ISIM 2
Pırıl Sağlıker Özkaynak, Yahya Sağlıker
VÜCUT SICA K LIĞ IN D A D E Ğ İŞ İK L İK L E R
3. Klinik Tıpta K arar Verme 8
Daniel B. Mark, 17. Ateş ve Hipertermi 91
Didem Arslan, Yahya Sağlıker Charles A. Dinarello, Jeffrey A. Geifand
Tuncay Özgünen
4. Klinik Tıpta Ekonomik Konular 14
Daniel B. Mark 18. Ateş ve DÖKÜNTÜ 95
Fatih Köse, Yahya Sağlıker Elaine T. Kaye, Kenneth M. Kaye
Mehmet Derya Onuk
5. Çevresel ve Mesleki Tehlikelerin Hastalık üzerine
Etkileri 19 19. Aniden Rahatsızlanan İnfekte Ateşli Hastaya
Howard Hu / Frank E. Speizer Yaklaşım 102
Serkan Yaraş, Yahya Sağlıker Tamar F. Barlam, Dennis L. Kasper
Ejder Küçükaltun, Yahya Sağlıker
6. Kadın Sağlığı 21
Anthony L. Komaroff, Celeste Robb-Nicholson, 20. Hipotermî ve Frostbite (Soğuk Çalması) 107
Andrea E. Dunaif Daniel F. Danzl
Serkan Yaraş, Yahya Sağlıker Kürşat Özşahin, Yahya Sağlıker

7. Gebelikte Görülen Tıbbi Bozukluklar 25

Robert L. Barbieri / John T, Repke
K ISIM 3
Kürşat Özşahin, Yahya Sağlıker
SİNİR SİSTEM İN İN FO N K SİYO N B O Z U K L U K L A R I
8. Adölesan Sağlık Sorunları 31
Mehul T. Dattani I Charles G.D. Brook 21. Baygınlık, Senkop, Baş dönmesi, ve Vertigo 111
Burhan Özdil, Yahya Sağlıker Robert B. Darojf, Mark D. Carlson
Yakup Sarıca
9. Geriatrik Tıp 36
Neil M. Resnick 22. Güçsüzlük, Myalji, Hareket Bozuklukları ve
Şule Oktay, Yusuf Karataş Dengesizlik 119
Richard K. Olney, Michael J Aminoff
10. Koruyucu Hekimliğin İlkeleri 46 Yakup Sarıca, Ayşe Filiz Koç
Maureen TConnelly / Thomas S. Inui
Bünyamin Sarıtaş, Yahya Sağlıker 23. Uyuşma, Karıncalanma, ve Duyu Kaybı 128
Arthur K. Asbury
11. Alternatif Tıp 49 Mün'ıfe Neyal
Adriane Fugh-Berman
Meral Keyer Uysal 24. Akut Konfüzyonel Durumlar ve Koma 132
Allan H. Ropper
B ölüm İk i Münife Neyal
HASTALIKLARIN ANA B U L G U L A R I VE TAKDİM
ŞEK İLLERİ 25. Afaziler ve Diğer Fokal Serebral Bozukluklar 140
M.-Marsel Mesulam
KISIM 1 Mustafa Yılmaz
AĞRI
26. Hafıza Kaybı ve Demans 148
12. Ağrı: Patofizyoloji ve Yönetim 55 Thomas D. Bird
Howard L. Fields, Joseph B. Martin Mustafa Yılmaz
Dilek Özcengiz
27. Uyku Bozuklukları 155
13. Göğüs Ağrısı ve Çarpıntı 60 Charles A. Czeisler, John W. Winkelman,
Thomas H. Lee Gary S. Richardson
Şeydi Okumuş, Yahya Sağlıker Yakup Sarıca
 43. Kilo Kaybı 250
Carol M. Reife
Birol Özer, Ender Serin , Yahya Sağlıker
28. Göz Hastalıkları 164
44. Gastrointestinal Kanamalar 252
Jonathan C. Horton
Loren Laine
Altan A.Özcan
Kürşat Özşahin, Yahya Sağlıker
29. Tat, Koku, ve İşitme Bozuklukları 179
45. Sarılık 255
Anıl K. Lalwani, James B. Snow, Jr,
Daniel S. Pratt, Marshall M. Kaplan
Yücel Akbaş
İdris Emir, Güven Gül, Yahya Sağlıker
30. Üst Solunum Yolu Enfeksiyonları 187
46. Abdominal Şişlik ve Assit 260
Marlene Durand, Michael Joseph
Robert M. Glickman
Yücel Akbaş, Cengiz Özcan
Mustafa Aktekin
31. Hastalıkların Oral Belirtileri 193
John S. Greenspan
Yücel Akbaş, Cengiz Özcan

47. Azotemi ve İdrar Anormallikleri 262

Bradley M. Denker, Barry M. Brenner
Ejder Küçükaltun, Yahya Sağlıker

32. Dispne ve Pulmoner Ödem 199 48. İnkontinans ve Alt Üriner Sistem Yakınmaları 268
Roland H. Ingram, Jr., Eugene Braunwahl Philippe E. Zimmern, John D. McConnell
Mehmet Aksoy Bülent Soyupak

33. Öksürük ve Hemoptizi 203 49. Sıvı ve Elektrolit Bozuklukları 271

Steven E. Weinberger, Eugene Braunwald Gary G. Singer, Barry M. Brenner
Cemal Sağlıker, Yahya Sağlıkçı- Tamer C. İnal

34. Kardiyak Üfürümlü Hastaya Yaklaşım 207 50. Asidoz ve Alkaloz 283
Patrick T. O'Gara, Eugene Braunwald Thomas D. DuBose, Jr.
İlyas Akdemir, Serdar Soydinç Tamer C. İnal

35. Hipertansiyonlu Hastaya Yaklaşım 211

Gordon H. Williams
Pırıl Sağlıker Özkayııak, Yahya Sağlıkçı-
51. Erektil Disfonksiyon 291
36. Hipoksi ve Siyanoz 214
Kevin T. McVary
Eugene Braunwald
Şaban Doran
Mehmet Necdet Akkuş
52. Menstürasyon Düzensizlikleri veKadınlarda Sık
37. Ödem 217
Görülen Diğer Jinekolojik Yakınmalar 295
Eugene Braunwald
Bruce R. Carr, Karen D. Bradshaw
Banu Karlılar,Sıddık Momin Adam, Yahya Sağlıker
Aytekin Altıntaş
38. Şok 222
53. Hirsutismus ve Virilizasyon 297
Ronald V. Maier
David A. Ehrmann
Fatma Yiğit,Yahya Sağlıker
Aytekin Altıntaş
39. Kardiyovasküler Kollaps, Kardiak Arrest ve
54. İnfertilite ve Fertilite Kontrolü 301
Ani Kardiyak Ölüm (SCD) 228
Janet E. Hail
Robert J. Myerburg, Agustin Castellanos
Aytekin Altıntaş
Dilek Özcengiz

55. Deri Hastalığı olan Hastaya Yaklaşım 305

40. Disfaji 233 Thomas J. Lawley, Kim B. Yancey
Raj K. Goyal Varol Aksungur
Figen Doran
56. Ekzema, Psöriazis, Kutanöz İnfeksiyonlar,
41. Mide Bulantısı, Kusma, ve Hazımsızlık 236 Akne ve Diğer Deri Bozuklukları 309
William L. Hasler Robert A. Swerlick, Thomas J. Lawley
Figen Doran Murat Durdu, Aydın Yücel

42. Diare ve Konstipasyon 241 57. İç Hastalıkların Deri Belirtileri 315

David A. Ahlguist, Michael Camitleri Jean L. Bolognia, Irwin M. Braverman
Kemal Kul, Mustafa Güçlü Aydın Yücel
 içindekiler

58. İmmünolojik Mekanizmalarla Gelişen Deri 71. İlaçların Yan (Toksik) Tesirleri 430
Hastalıkları 331 Alastair J.J. Wood
Kim B. Yancey, Thomas J. Lawley Yusuf Karataş
Soner Uzun
72. Otonomik Sinir Sisteminin Fizyolojisi ve
59. Kütanöz İlaç Reaksiyonları 336 Farmakolojisi 438
Robert S. Stern, Olivier M. Chosidow, Lewis Landsberg, James B. Young
Bruce U. Wintroub Cemil Göçmen
Varol Aksungur
Bölüm Beş
60. Fotosensitivite ve Diğer Işık Reaksiyonları 342 BESLENME
David R. Bickers
Gül Denli, Sühan Günaştı 73. Besin Gereksinimleri ve Diyet Değerleri 451
•CİSİM 10 Johanna Dwyer
HEMATOLOJİK D EĞ İŞİKLİKLER Sema Şimşek, Yahya Sağlıker

61. Anemiler ve Polisitemiler 348 74. Kötü Beslenme ve Beslenmeye ilişkin

John W. Adamson, Dan L. Longo Değerlendirme 455
Yurdanur Kıiınç Charles H. Halsted
Sema Şimşek, Yahya Sağlıker
62. Kanama ve Tromboz 354
Robert I. Handin 75. Vitamin ve Eser Mineral Eksikliği ve Fazlalığı 461
Cengiz Beyan, Oral Nevruz Robert M. Russell
Tamer C. İnal
63. Lenfadenomegali ve Splenomegali 360
Patrick H. Henry, Dan L. Longo 76. Enteral ve Parenteral Nütrisyon Tedavisi 470
Emel Gürkan Lyn Howard
Ender Serin, Cengiz Pata
64. Granülositlerin ve Monositlerin Hastalıkları 366
Steven M. Holland, John I. Gallin 77. Obezite 479
Celalettin Camcı Jeffrey S, Flier
Kemal Bakır
Tıpta ve Fizyolojide Nobel Ödülü, 1990 374
Joseph Edward Murray t Edward D om ail Thomas 78. Yeme Bozuklukları 486
Işıl Öcal B. Timothy Walsh
Ejder Küçükaltun, Yahya Sağlıker
Bölüm Üç
GENETİK VE HASTALIK Holüm Altı
ONKOLOJİ VE HEMATOLOJİ
65. İtısan Genetiğinin İlkeleri 375
J. tarry Jameson, Peter Kopp KISIM 1
Halil ^asap, Mülkiye Kasap N E G P L A ST IK H A STA LIK LA R

66. Kromozom Düzensizlikleri 396

79. Kanserli Hastaya Yaklaşım 491
Terry Hassold, Stuart Schwartz
Dan L. Longo
Halil Kasap, Mülkiye Kasap
Şükran Sevimli, Yahya Sağlıker
67. Mitokondrial Genetik Bozuklukların Neden Olduğu
80. Kanserin Önlenmesi ve Erken Saptanması 497
Hastalıklar 404
Otis W. Brawley, Barnett S. Kramer
Donald R. Johns
Mehmet Horoz, Yahya Sağlıker
Halil Kasap, Mülkiye Kasap

68. Tarama, Danışma ve Genetik Bozuklukların 81. Kanser Genetiği 503

Önlenmesi 407 Francis S. Collins, Jeffrey M, Trent
Susan Miesfeldt, J. Larry Jameson Mülkiye Kasap, Halil Kasap
Mülkiye Kasap, Belde Kasap
82. Kanserin Hücre Biyolojisi 509
69. Gen Tedavisi 412 Robert G. Fenton, Dan L. Longo
Mark A. Kay, David W. Russell Kemal Bakır
Halil Kasap, Mülkiye Kasap
83. Angiogenez 517
Tipta vs Fizyolojide Nehri Ödülü, 1905 Judah Folkman
Robert Koch Kemal Bakır
Mülkiye Kasap, Halil Kasap, Işıl Öcal
84. Kanser Tedavisinin Prensipleri 530
Bolum üort Edward A. Sausville, Dan L. Longo
K L İ N İ K EARMASOl OJİ Yurdanur Kıiınç

70. İlaçla Tedavi İlkeleri 419 85. Kanserli Hastalarda İnfeksiyonlar 547
John A. Oates, Dan M. Roden, Grant R. Wilkinson Robert Finberg
Şule Oktay, Yusuf Karataş Hayrettin Akdeniz
86. Melanoma ve Diğer Deri Kanserleri 554 Michael C. Perry, Dan L. Lonp
Arthur J. Sober, Howard K. Koh, Gregory P. Wittenberg, Belgin Büyükakıllı
Carl V. Washington, Jr.
Celalettin Camcı Kİ.SİM 2
H KM ATOPOEZ BOZUKLUKLARI
87. Baş Boyun Kanseri 559
Everett E. Vokes 104. Hematopoez 653
Yücel Akbaş Peter J. Quesenberry, Gerald A. Colvin
Mustafa Dikilitaş, İsmet Aydoğıiu
88. Akciğer Neoplazmları 562
John D. Minna 105. Demir Eksikliği ve Diğer Hipoproliferatif Anemiler 660
Ali Özdülger John W. Adamson
Oral Nevruz, Birol Güvenç
89. Meme Kanseri 571
Marc E. Lippman 106. Hemoglobinopatiler 666
Melek Koksal Erkişi Edward J. Benz, Jr.
Yurdanur Kılmç
90. Gastrointestinal Kanal Kanserleri 578
Robert J. Mayer 107. Megaloblastik Anemiler 674
Alper Akınoğlu, H. Mehmet Haznedar Bernard M. Babior, H. Franklin Bunn
Çağatay Ünsal, Birol Güvenç
91. Karaciğer ve Safra Yolları Tümörleri 588
Jules L. Dienstag, Kurt J. Isselbacher 108. Hemolitik Anemiler ve Akut Kan Kaybı 681
Birol Özer, Ender Serin, Yahya Sağlıker H. Franklin Bunn, Wendell Rosse
Pervin Topçuoğlu, Meltem KurtYüksel, Yahya Sağlıker
92. ankreas Kanseri 591
Robert J. Mayer 109. Aplastik Anemi, Miyelodisplazi, ve İlişkili İlik Yetmezliği
Mahmut Akgöz,Yahya Sağlıker Sendromları 692
Seal S. Young
93. Gastrointestinal Sistem ve Pankreasta Endokrin
Mustafa Dikilitaş, İsmet Aydoğdü
Tümörleri 593
Robert T. Jensen 110. Polistemi Vera ve Diğer Miyeloproliferatif
Yüksel Gümürdülü,Yahya Sağlıker Hastalıklar 701
604 Jerry L. Spivak
94. Mesane ve Böbrek Hücre Karsinoması
Howard I. Seher, Robert J. Motzer Süleyman L. Dinçerler
Bülent Soyupak
111. Akut ve Kronik Miyeloid Lösemiler 706
95. Prostat Bezinin Hiperplazik ve Malign Hastalıkları 608 Me ir Wetzler, John C. Byrd, Clara D. Bloomfield
Howard /. Seher Berksoy Şahin
Atilla Arıdoğan
112. Lenfoid Hücre Malignensileri 715
James O. Armitage, Dan L. Longo
96. Testis Kanseri 616
Zahit Bolaman
Robert J. Motzer, George J. Bosl
Nihat Satar 113. Plazma Hücre Hastalıkları 727
Dan L. Longo
97. Jinekolojik Kanserler 620
İmdat Dilek
Robert C. Young
Aytekin Altıntaş 114. Transfüzyon Biyolojisi ve Tedavisi 733
Jeffery S. Dzieczkowski, Kenneth C. Anderson
98. Yumuşak Doku ve Kemik Sarkomları ve Kemik
Gürhan Kadıköylü, Zahit Bolaman
Metastazları 625
Shreyaskumar R. Patel, Robert S. Benjamin 115. Kemik İliği ve Kök Hücre Transplantasyonu 739
Elif Güler Frederick R. Appelbaum
Atila Tanyeli
99. Primer Yeri Bilinmeyen Metastatik Kanser 628
Richard M. Stone K ISIM 3
Elif Güler .'IEM OSTAZ BO ZU K LU K LA RI

100. Paraneoplastik Sendromlar 632 116. Trombosit ve Damar Duvarı Bozuklukları 745
Bruce E. Johnson Robert I. Handin
Fatin Koçak, Yahya Sağlıker Yurdanur Kılmç

101. Paraneoplastik Nörolojik Sendromlar (PNNS) 636 117. Koagülasyon ve Tromboz Bozuklukları 751
Muhammad T. Al-Lozi, Alan Pestronk Robert I. Handin
Süleyman Alıcı Emel Gürkan

102. Onkolojik Aciller 642 118. Antikoagülan, Fibrinolitik, ve Antitrombostik Tedavi 758
Rasim Gucalp, Janice Dutcher Robert I. Handin
Kazım Uygun, İrfan Çiçin A.Uğur Ural
103. Kanser ve Tedavisinin Geç Sonuçları 650 Tıpta "e Fh.yMojUe el O lii'ii, U. 0
 içindekiler

Karl Landsreiner
Klinik Yaklaşım 839
Işıl Öcal King K. Holmes
Tıpta ve Fizyolojide Nobel Ödülü, 1962 Ali Kaya

Francis Harry Compton Crick, James Dewey Watson, 133. Pelvik İnflamatuar Hastalık 848
Maurice Hugh Frederick Wilkins King K. Holmes, Robert C. Brunham
Işıl Öcal ytekin Altıntaş
KISIM 3
Bölüm Yedi
K LİN İK SE N D R O M LA R : HASTANE KÖKENLİ
EN FEK SİYO N H A STA LIK LA R I
EN FEK SİYO N LA R
KISIM 1
EN FEKSİYON HA STA LIKLA RIN D A T E M E L DÜ ŞÜ N CELER
134. Hastanede Enfeksiyon Kontrolü 853
Robert A. Weinstein
119. Enfeksiyon Hastalıklarına Giriş: Konak-Parazit Aylin Dalkıran, Neşe Saltoğlu
İlişkileri 763
Lawrence C. M adoff, Dennis L. Kasper 135. Hastanede Edinilmiş ve Damar İçi Araca İlişkin
Mesut Yılmaz, Recep Öztürk Enfeksiyonlar 857
Dori F. Zaleznik
120. Mikrobiyal Patogenezin Moleküler Mekanizmaları 767 Neşe Saltoğlu
Gerald B. Pier
Bilgül Mete, Recep Öztürk 136. Transplant Alıcılarında Enfeksiyonlar 860
Robert Finberg, Joyce D. Fingeroth
121. İnfeksiyon Hastalıklarının Laboratuar Tanısı 775 Neşe Saltoğlu
Andrew B. Onderdonk KISIM 4
Recep Öztürk B A K T E R İY E L H A STA LIK LA RIN fEDA VİSİN E YAKLAŞIM

122. Bağışıklama Prensipleri ve Aşı Kullanımı 780

Gerald T. Keusch, Kenneth J. Bart 137. Bakteriye! Enfeksiyonların Tedavi ve Profilaksisi 867
Aysan Murtezaoğlu, Recep Öztürk Gordon L. Archer, Ronald E. Polk
Neşe Saltoğlu
123. Uluslararası Seyahatte Sağlık Önerileri 793 KISIM 5
J.S. Keystone, P.E. Kozarsky G R A M -P O Z İT İF B A K T E R İL E R İN NEDEN OLDUĞU
Aygül Doğan Çelik, Recep Öztürk E N FEK SİYO N LA R
K ISIM 2
K LİN İK SK N D RO M LA R :TO PLU M KAYNAKÇI
İN FEK SİY O N LA R 138. Pnömokokların Neden Olduğu Enfeksiyonlar 882
Daniel M. Musher
Yeşim Taşova
124. Sepsis ve Septik Şok / 799
Robert S. Munford 139. Stafilokokların Neden Olduğu Enfeksiyonlar 889
Ali Kaya Jeffrey Parsonnet, Robert L. Deresiewicz
Yeşim Taşova
125. Nedeni Bilinmeyen Ateş 804
Jeffrey A. Gelfand 140. Streptokoklar ve Enterokoklar ile Oluşan
Ali Kaya Enfeksiyonlar 901
Michael R. Wessels
126. İnfektif Endokardit 809
Yeşim Taşova
Adolf W. Karchmer
Ali Kaya 141. Difteri, Diğer Korinebakteriler ile Oluşan
Enfeksiyonlar ve Antraks 909
127. Isırık ve Yanıkların İnfeksiyöz Komplikasyonları 817
Randall K. Holmes
Lawrence C. Madoff /
Yeşim Taşova
Ali Kaya
142. Listeria Monocytogenezin neden olduğu
128. Deri, Kas, ve Yumuşak Doku İnfeksiyonları 821
Enfeksiyonlar 915
Dennis L. Stevens
Anne Schuchat, Claire V. Broome
Ali Kaya
Aydın Karaarslan
129. Osteomiyelit 825 143. Tetanoz 918
James H. Maguire Elias Abrutyn
Ali Kaya
Aydın Karaarslan, Ebru Us

130. Batın içi İnfeksiyonlar ve Abseler 829 144. Botulizm 920

Dori F. Zaleznik, Dennis L. Kasper Elias Abrutyn
Şaban Çavuşlu Aydın Karaarslan, Emel Sesli Çetin

131. Akut İnfeksiyöz İshaller ve Bakteriyel Besin 145. Gazlı Gangren, Antibiyotik İlişkili Kolit, ve Diğer
Zehirlenmesi 834 Clostridial Enfeksiyonlar 922
Joan R. Butterton, Stephen B. Calderwood Dennis L. Kasper, Dori F. Zaleznik
Oral Öncül Devran Gerçeker <isı M 6
132. Cinsel Yolla Bulaşan Hastalıklar: Genel Bakış ve
 162. Veba ve Diğer Yersinia Enfeksiyonları 993
Grant L. Campbell, David T Dennis
A. Seza İnal
146. Meningokok İnfeksiyonları 927
Robert S. Munford 163. Kedi-Tırmığı Hastalığı Ve Bartonella EnfeksiyonlarılOOl
Şaban Esen Lucy Stuart Tompkins
A.Seza İnal
147. Gonokokkal İnfeksiyonlar 931
Sanjay Ram, Peter A. Rice 164. Donovanoz 1004
Dilek Arman Gavin Hart
A.Seza İnal
148. Moraxella catarrhalis ve Diğer Moraxella Türleri 938
Daniel M. M usher
Hakan Leblebicioğlu

149. Haemophilus Enfeksiyonları 939

165. Nokardiyoz 1006
Timothy F. Murphy
Gregory A. Filice
Ahmet Saniç
Gülden Ersöz
150. HACEK Grubu ve Çeşitli Gram-Negatif Bakterilerle
166. Aktinomikoz 1008
Meydana Gelen İnfeksiyonlar 942
Thomas A. Russo
Dennis L. Kasper, Tamar F. Barlam
Gülden Ersöz
Gülay Yetkin, Rıza Durmaz
167. Miks Anaerobik İnfeksiyonlar 1011
151. Legionella İnfeksiyonu 945
Dennis L. Kasper
Feng-Yee Chang, Victor L. Yu
Gülden Ersöz
Gülay Yetkin, Rıza Durmaz

152. Boğmaca ve Diğer Bordetella Enfeksiyonları 949

Scott A. Halperin
Gülay Yetkin, Rıza Durmaz

153. Gram-Negatif Enterik Basiller Tarafından 168. Antimikobakteriyel Ajanlar 1017

Oluşturulan Hastalıklar 953 Paul W. Wright, Richard J. Wallace, Jr.
Thomas A. Russo Ali Kocabaş, Sedat Kuleci
Gülay Yetkin, Rıza Durmaz
169. Tüberküloz 1024
154. Helicobacter pylori İnfeksiyonları 960 Mario C. Raviglione, Richard J. O'Brien
John C. Atherton, Martin J. Blaser Ali Kocabaş , Sedat Kuleci
Necla Tülek
170. Lepra (Hansen Hastalığı) 1035
155. Pseudomonas Türleri ve İlişkili Mikroorganizmalara Robert H. Gelber
Bağlı İnfeksiyonlar 963 Gülden Ersöz
Christopher A. Ohl, Matthew Pollack
171. Nontüberküloz Mikobakterilere Bağlı İnfeksiyonlar 1040
Necla Tülek
Bernard Hirschel
156. Salmonelloz (Tifo) 970 Gülden Ersöz
Camnıie F. Lesser, Samuel l. Miller
Necla Tülek

157. igelloz 975

Gerald T. Keusch
Necla Tülek 172. Sifilis 1044
Sheila A. Lukehart
158. Campylobacter ve İlişkili Türlere Bağlı Özlem Kandemir
Enfeksiyonlar 978
Martin J. Blaser 173. Endemik Treponematosis 1053
A.Seza İnal Sheila A. Lukehart
Özlem Kandemir
159. Kolera ve Diğer Vibriyo Hastalıkları 980
Gerald T. Keusch, Robert L. Deresiewicz, 174. Leptospirosis 1055
Matthew K. Waldor Peter Speelman
A.Seza İnal Özlem Kandemir

160. Bruselloz 986 175. Tekrarlayan Ateş 1058

M. Monir Madkour, Dennis L. Kasper David T. Dennis, Grant L. Campbell
A.Seza İnal Özlem Kandemir

161. Tülaremi 990 176. Lyme Borreliosis 1061

Richard F. Jacobs Allen C. Steere
A. Seza İnal Özlem Kandemir
177. Riketsiyal Hastalıklar 1065 191. İnsan Retrovirüsleri 1131
David Walker, Didier Raoult, J. Stephen Dumler, Anthony S, Fauci, Dan L. Longo
Thomas Marrie Mehmet Horoz, Yahya Sağlıker
Ayhan A kçayiğit, Sıddık Momin Adam, Yahya Sağlıker
192. Viral Gastroenteritler 1135
178. Mikoplazma Enfeksiyonları 1073 Harry B. Greenberg
William M. McCormack İbrahim Halil Özerol
Ayhan A kçayiğit, Sıddık Momin Adam,Yahya Sağlıker
193. Enterovirüsler ve Reovirüs 1138
179. Klamidya Enfeksiyonları 1075 Jeffrey l. Cohen
Walter E. Stamm Mustafa Namıduru
Ayhan A kçayiğit, Sıddık Momin Adam, Yahya Sağlıker
194. Kızamık (Rubeola) 1143
Anne Gershon
Cemal Sağlıker, Yahya Sağlıker

195. Kızamıkçık (Rubella, Alman Kızamığı) 1145

180. Tıbbi Viroloji 1084
Anne Gershon
Fred Wang, Elliott Kieff
İbrahim Halil Özerol
Selma Ay
196. Kabakulak 1147
181. Antiviral Kemoterapi, (Antiretroviral İlaçlar Hariç) 1092
Anne Gershon
Raphael Dolin
İbrahim Halil Özerol
Çimen Karasu
197. Kuduz Virüsü ve Diğer Rhabdovirüsler 1149
Lawrence Corey
, îK C.-Î.K tU
İdris Şahin

182. Herpes Simplex Virüsler 1100 198. Eklembacaklı (Arthropod) ve Kemirgen Kaynaklı
Lawrence Corey Virüslerin Neden Olduğu Enfeksiyonlar 1152
Murat Ertürk C.J. Peters
Metin Otkun
183. Varisella-Zoster Virüs Enfeksiyonları 1106
Richard J. Whitley 199. Filoviridae (Marburg ve Ebola Virüsleri) 1166
Murat Ertürk C.J. Peters
İbrahim Halil Özerol
184. İnfeksiyöz Mononükleoz’u da İçeren Epstein-Barr
Virüs İnfeksiyonları 1109
Jeffrey I. Cohen
Fadile Yıldız Zeyrek

185. Sitomegalovirüs ve İnsan Herpesvirüs Tipleri

200. M antar Enfeksiyonlarının Tanımı ve Tedavisi 1168
6 , 7 , ve 8 111
John E. Bennett
Martin S. Hirsch
Ali Matur, İrem Matur
Çiğdem Kuzucu
201. Histoplazmosis 1171
186. Smallpoks, Vaksinya ve Diğer Poksvirüsler 1115
John E. Bennett
Fred Wang
Ali Matur, Ebru Derici
Çiğdem Kuzucu
202. Coccidioidomycosis 1172
187. Parvovirüs 1117
John E. Bennett
Neil R. Blacklow
Ali İrfan Güzel, Ali Matur
Çiğdem Kuzucu
203. Blastomikozis 1173
188. İnsan Papilloma virüsleri 1118
John E. Bennett
Richard C. Reichman
Mukadder Çalıkoğlu
Çiğdem Kuzııcu
204. Kriptokokkosis 1174
John E. Bennett
Meral Ürünsak , Ali Matur

189. Sık Rastlanan Solunum Enfeksiyonları 1120 205. Candidiyazis 1176

Raphael Dolin John E. Bennett
Mehmet Sait Tekerekoğlu Mukadder Çalıkoğlu

190. influenza 1125 206. Asperjillozis 1178

Raphael Dolin John E. Bennett
Hatice Özbilge Mukadder Çalıkoğlu
207. Mukormikoz 1179 222. Şistozomiazis ve Diğer Trem atod İnfeksiyonları 1242
John E. Bennett Adel A.F. Mahmoud
Fadile Yıldız Zeyrek Aynur Atilla , Mustafa Sünbül

208. Diğer M ikozlar ve Algal İnfeksiyonlar 1180 223. Sestodlar 1248

John E. Bennett A. Clinton White, Jr., Peter F. Weller
Mukadder Çalıkoğlu Alper Akınoğlıı. Gürhan Sakınan

209. Pnömosistitis karini İnfeksiyonıı 1182

Peter D. Waller
Mukadder Çalıkoğlu Alper Akınoğlıı. Gürhan Sakman, Işıl Öcal

210. Parazit Enfeksiyonlu H astalara Yaklaşım 1185

Peter F. Weller
Ayhan Akçayiğit, Sıddık Momin Adam,Yahya Sağlıker
224. Kalp Hastalıklı H astaya Yaklaşım 1253
211. Parazit Enfeksiyonlarının L ab o ratu ar Teşhisi 1186
Eugene Braunwald
Charles E. Davis
Burhan Özdil. Yahya Sağlıker
Ayhan Akçayiğit. Sıddık Momin Adam.Yahya Sağlıker
225. Kardiyovasküler Sistemin Fizik Muayenesi 1255
212. P arazit Enfeksiyonlarının Tedavisi 1192
Robert A. ORourke, Eugene Braunwald
Thomas A. Moore
Bünyamin Sarıtaş, Yahya Sağlıker
Ayhan Akçayiğit. Sıddık Momin Adam. Yahya Sağlıker
226. Elektrokardiyografi 1262
Ary L. Goldberger
Ahmet Birand
213. Amebiazis ve Serbest Yaşayan Amipler ile
Enfeksiyon 1199 227. Kalbin Noninvazif Görüntülenm esi: Ekokardiyografi
Sharon L. Reecl ve Nükleer Kardiyoloji 1271
Ayhan Akçayiğit. Sıddık Momin Adam, Yahya Sağlıker Rick A. Nishimııra, Raymond J. Gibbons, A. Jamil Tajik
Ahmet Çamsan
214. Sıtma ve Babesiozis: Alyuvar Parazitlerinin Sebep
Olduğu Hastalıklar 1203 228. Tanısal K alp K ateterizasyonu ve Anjiyografisi 1277
Nicholas J. White, Joel G. Breman Donald S. Bairn, William Grossman
Ayhan Akçayiğit. Sıddık Momin Adam.Yahya Sağlıker Ahmet Çamsan

215. Leishmaniazis 1213

Barbara L. Herwaldt
Ayhan Akçayiğit, Sıddık Momin Adam, Yahya Sağlıker
229. Bradiaritm iler: Sinüs Düğümü ve AV İletim
216. Tripanozomiazis 1218
Bozuklukları 1283
Louis V. Kirchhojf
Mark E. Josephson, Peter Zimetbaum
Şaban Gürcan
Feridun Koşar, Ergün Topal
217. Toksoplazma Enfeksiyonu 1222
230. Taşiaritm iler 1292
Lloyd H. Kasper
Mark E. Josephson, Peter Zimetbaum
Müşerref Tatman Otkun
Feridun Koşar. Ergün Topal
218. Protozoal Intestinal İnfeksiyonlar ve Trikomoniyoz 1227
Peter F. Weller
İrfan Şencan

231. Normal ve Anormal M iyokard Fonksiyonları 1309

Eugene Braunwald
Mehmet Necdet Akkuş
219. Trichinella ve Diğer Doku Nematodları 1231
Peter F. Weller, Leo X. Liu 232. Kalp Yetersizliği 1318
Feza Otağ Eugene Braunwald
Ahmet Birand
220. İnce Barsak Nematodlar 1233
Peter F. Weller, Thomas B. Nutman 233. K ardiyak Transplantasyon 1329
Feza Otağ John S. Schıveder
Nehir Sucu, Esra Kocadurmuşoğlu
221. Filariyoz ile İlgili İnfeksiyonlar (Loaz, Onkoserkoz,
ve Drakunkuloz) 1237 234. Erişkinde Konjenital Kalp Hastalığı 1331
Thomas B. Nutman, Peter F. Weller William F. Friedman, John S. Child
Gülay B ö rek çi, Feza Otağ Mesut Demir
 İçindekiler

235. Romatizma! Ateş 1340 250. Solunum Fonksiyonu Bozuklukları 1446

Edward L. Kaplan Steven E. Weinberger, Jeffrey M. Drazen
Mehmet Necdet Akkuş Serap Hastürk

236. Kalp Kapak Hastalıkları 1343 251. Solunum Sistemi Hastalıklarında Tanı Yöntemleri 1453
Eugene Braunwald
Vedat Davutoğlu Steven E. Weinberger, Jeffrey M. Drazen
Bahar Ulubaş
237. Kor Pulmonale 1355
Eugene Braunwald K ISIM 2
M. Hakan Dinçkal SOLUNUM S İS T E M İ HASTAL IK LA R I

238. Kardiyomiyopatiler veMiyokarditler 1359

Joshua Wynne, Eugene Braunwald 252. Astım 1456
İlyas Akdemir E.R. McFadden, Jr.
Serap Hastürk
239. Perikard Hastalığı 1365
Eugene Braunwald 253. Hipersensitivite Pnömonisi ve Eozinofili ile Seyreden
Ahmet Birand Pulmoner İnfiltrasyonlar 1463
Joel N, Kline, Gary W. Hunninghake
240. Kardiyak Tümörler, Sistemik Hastalıkların Kardiyak
Serap Hastürk
Bulguları ve Travmatik Kardiyak Yaralanma 1372
Wilson S. Colucci, Daniel T. Price 254. Çevresel Akciğer Hastalıkları 1467
Nehir Sucu, Esra Kocadurmuşoğlu Frank E. Speizer
K ISIM 4 Bahar Ulubaş
DAMAR H A STA LIĞ I
255. Pnömoni, Nekrotizan Pulmoner Akciğer
241. Aterosklerozun Patogenezi 1377 Enfeksiyonları (Akciğer Apsesi) 1475
Peter Lihhy atthew E. Levison
Mehmet Kanadaşı Bahar Ulubaş

242. Aterosklerosizin Önlenmesi ve Tedavisi 1382 256. Bronşiektazi 1485

Peter Lihhy Steven E. Weinberger
Çimen Karasu Bahar Ulubaş

243. Akut Miyokard İnfarktüsü 1386 257. Kistik Fibrosis 1487

Elliott M. Antman, Eugene Braunwald Richard C. Boucher
Ahmet Birand Tamer C, İnal

244. İskemik Kalp Hastalığı 1399 258. Kronik Bronşit, Amfizem, ve Hava Yolu
Andrew P. Selwyn, Eugene Braunwald Obstrüksiyonu 1491
İlyas Akdemir, Murat Akçay, Ahmet Birand Eric G. Honig, Roland H. Ingram, Jr.
Ali Özdülger
245. Perkutan Koroner Revaskülarizasyon 1410
Donald S. Baim 259. İnterstisyel Akciğer Hastalıkları 1499
Nehir Sucu, Esra Kocadurmuşoğlu Talmadge E. King, Jr.
Nesimi Eren , Akın Eraslan Balcı
246. Hipertansif Vasküler Hastalıklar 1414
Gordon H. Williams 260. Primer Pulmoner Hipertansiyon 1506
Hasan Sabit Sağlıker, Pırıl Sağlıker Özkaynak, Stuart Rich
Yahya Sağlıker Nesimi Eren , Akın Eraslan Balcı

247. Aort Hastalıkları 1430 261. Pulmoner Tromboembolizm 1508

Victor J. Dzau, Mark A. Creager Samuel Z. Goldhaber
Fatma Yiğit, Yahya Sağlıker
İsmail Hanta, Ali Kocabaş
248. Ekstremitelerin Damarsal Hastalıkları 1434
262. Plevra, Mediasten, ve Diafragma Hastalıkları 1513
Mark A. Creager, Victor J. Dzau
Richard W. Light
Nehir Sucu , Ali Gül
Nesimi Eren , Akın Eraslan Balcı
t;İ l.T H
263. Yentilasyon Bozuklukları 1517
B ölüm Dokuz Eliot A. Phillipson
SOLUNUM SİSTEM İN İN H ' Nesimi Eren, Akın Eraslan Balcı

K'SIM i 264. Uyku Apnesi 1520

l'ANI Eliot A. Phillipson
Nesimi Eren , Akın Eraslan Balcı
249. Solunum Sistemi ile İlgili Hastalığı Olan Hastaya
Yaklaşım 1443 265. Akut Respiratuar Distres Sendromu 1523
Jeffrey M. Drazen, Steven E. Weinberger Marc Moss, Roland H. Ingram, Jr.
Serap Hastürk Nesimi Eren , Akın Eraslan Balcı
266. Mekanik Ventilasyon Desteği 1526
Edward P. Ingenito, Jeffrey M. Drazen
Dilek Özcengiz

267. Akciğer Transplantasyonu 1531 Nihat Satar , Işıl Öcal

Janet R. Maurer
Ali Özdülger

Işıl Öcal

282. Gastrointestinal Hastalığı olan Hastaya Yaklaşım 1631

Daniel K. Podolsky, Kurt J. Isselbacher
268. Böbrek Fonksiyonunda Bozulmalar 1535 Macit Ümran Sandıkçı
Robert M. Brenner, Barry M. Brenner
283. Gastrointestinal Endoskopi 1635
Bülent Tokgöz , Cengiz Utaş
Mark Topazian
269. Akut Böbrek Yetmezliği 1541 Macit Ümran Sandıkçı
Hugh R. Brady, Barry M. Brenner
284. Özofagus Hastalıkları 1642
Hülya Taşkapan
Raj K. Goyal
270. Kronik Böbrek Yetmezliği 1551 Macit Ümran Sandıkçı
Karl Skorecki, Jacob Green, Barry M. Brenner
Mehdi Yeksan , H. Zeki Tonbul 285. Peptik Ülser Hastalığı ve İlgili Hastalıklar 1649
John Del Valle
271. Böbrek Yetmezliği Durumunda Diyaliz Tedavisi 1562 Macit Ümran Sandıkçı
Ajay K. Singh, Barry M. Brenner
Necati Kıralp, Süha Kıralp, Yahya Sağlıker 286. Absorbsiyon Bozuklukları 1665
Henry J. Binder
272. Böbrek Yetmezliği Tedavisinde Transplantasyon 1567 Murat Öksüz, Yahya Sağlıker
Charles B. Carpenter, Edgar L. Milford.
Mohamed H. Sayegh 287. İnflamatuar Barsak Hastalığı 1679
Zeki Yılmaz Sonia Friedman, Richard S. Blumberg
Fatih Yüksel Işıksal, Yahya Sağlıker
273. Glomeruler Hastalıkların Patogenezi 1572
Hugh R. Brady, Barry M. Brenner 288. İrritabl Barsak Sendromu 1692
Sevgi Mir Chung Owyang
Bülent Yıldırım
274. M ajor Glomerül Hastalıkları 1580
Hugh R. Brady, Yvonne M. O’Meara, Barry M. Brenner 289. Barsak ve Peritonun Divertiküler, Vasküler ve
Saime Paydaş Diğer Hastalıkları 1695
Kurt J. Isselbacher, Alan Epstein
275. Sistemik Hastalıklarla Birlikte olan Glomerül Bahri Abaylı, Yahya Sağlıker
Hastalıkları 1590
Yvonne M. O'Meara, Hugh R. Brady, Barry M. Brenner 290. Akut intestinal Obstrüksiyon 1703
Saime Paydaş William Silen
Alper Akınoğlu, Cem Kaan Parsak
276. Kalıtsal Tübüler Hastalıklar 1598
John R. Asplin, Fredric L. Coe 291. Akut Apandisit 1705
Aytül Noyan William Silen
Alper Akınoğlu, Cem Kaan Parsak
277. Böbreğin Tübülointerstisyel Hastalıkları 1606
Alan S.L. Yu, Barry M. Brenner
Ayşa Balat

278. Böbrekte Damarsal Hasarlanma 1610 292. Karaciğer Hastasına Yaklaşım 1707
Kamal F. Badr, Barry M. Brenner Marc Ghany, Jay H. Hoofnagle
Reha Erkoç, Hayriye Sayarlıoğlu Hikmet Akkız

279. Böbrek Taşı Hastalığı 1615 293. Karaciğer Fonksiyonlarının Değerlendirilmesi 1711
John R. Asplin, Fredric L. Coe, Murray J. Favus Daniel S. Pratt, Marshall M. Kaplan
Nihat Satar Tamer C. İnal

280. Üriner Sistem Enfeksiyonları ve Piyelonefrit 1620 294. Bilirubin Metabolizması ve Hiperbilirubinemiler 1715
Walter E. Stamm Paul D. Berk, Allan W. Wolkoff
Ayşe Balat Tamer C. İnal

281. Üriner Sistem Obstrüksiyonları 1627 295. Akut Viral Hepatitler 1721
Julian L. Seifter, Barry M. Brenner Jules L. Dienstag, Kurt J. Isselbacher
Nihat Satar Bülent Değertekin
296. Toksik ve İlaca Bağlı Hepatitler 1737 Abdullah Canatroğlu
Jules L. Dienstag, Kurt J. Isselbacher 311. Sistemik Lupus Eritematozus 1922
Selahattin Ünal, Tarkan Karakan Bevra Hannahs Hahn
Abdullah Canatroğlu
297. Kronik Hepatitler 1742
Jules L. Dienstag, Kurt J. Isselbacher 312. Romatoid Artrit 1928
İbrahim Doğan Peter E. Lipsky
Erkan Kozanoğlu, Abdullah Canatroğlu
298. Alkolik Karaciğer Hastalığı 1752
Mark E. Mailliard, Michael F. Sorrell 313. Sistemik Skleroz (Skleroderma) 1937
Şükrü Dumlu, Tarkan Karakan Bruce C. Gilliland
Şeminur Haznedaroğlu
299. Siroz ve Komplikasyonları 1754
Raymond T. Chung, Daniel K. Podolsky 314. Sjögren Sendromu 1947
Fatin Koçak, Yahya Sağlıker Haralampos M. Moutsopoulos
Berna Göker
300. Karaciğeri Etkileyen Metabolik, Genetik ve İnfiltratif
Hastalıklar 1767 315. Ankilozan Spondilit, Reaktif Artrit, ve Tanımlanmamış
Daniel K. Podolsky Spondiloartropati 1949
Gülleyla Kılıç, Nurcan Araş Ateş Joel D. Taurog, Peter E. Lipsky
Hüseyin T E. Özer
301. Karaciğer Nakli 1770
Jules L. Dienstag 316. Behçet Sendromu 1956
Özgür Yağmur Haralampos M. Moutsopoulos
Hüseyin T. E. Özer
302. Safra Kesesi ve Safra Yollarının Hastalıkları 1776
Norton J. Greenberger, Gustav Paumgartner 317. Vaskülit Sendromları 1956
Sunay Sandıkçı Anthony S. Fauci
K ISIM 3 Hüseyin T. E. Özer
PANKREAS H A STA LIK LA R I
318. Sarkoidoz 1969
303. Pankreas Hastalıklı Hastaya Yaklaşım 1788 Ronald G. Crystal
Phillip P. Toskes, Norton J. Greenberger Berna Göker
Sunay Sandıkçı
319. Amiioidoz 1974
304. Akut ve Kronik Pankreatit 1792 Jean D. Sipe, Alan S. Cohen
Norton J. Greenberger, Phillip P. Toskes Şeminur Haznedaroğlu
Sunay Sandıkçı
Bölüm Oniki K ISIM 3
İMMÜN SİSTEM , BAĞ DOKUSU V E E K L E M E K L E M H A STA LIK LA R I
H A ST A LIK LA R I
320. Eklem ve Kas İskelet Sistemi Hastalıklarına
KİŞİM i
Yaklaşım 1979
İMMÜN S İST E M H A STA LIK LA R I
John J. Cush, Peter E. Lipsky
Abdullah Milcan
305. İmmün Sisteme Giriş 1805
Barton F. Haynes, Anthony S. Fauci 321. Osteoartrit 1987
Abdullah Canataroğlu, Birol Güvenç Kenneth D. Brandt
Nurgül Arıncı İncel
306. M ajor Doku Uygunluğu Gen Kompleksi 1830
Gerald T. Nepom, Joel D. Taurog 322. Gut ve Diğer Kristal Artropatiler 1994
Hüseyin T.E. Özer Antonio J. Reginato
Günşah Şahin
307. Otoimmünite ve Otoimmün Hastalıklar 1839
Peter E. Lipsky, Betty Diamond 323. İnfeksiyöz Artritler 1998
Didem Arslan, Yahya Sağlıker Scott J. ThalerJam es H. Maguire
Selda Bağış
308. Primer İmmün Yetmezlik Hastalıkları 1843
Max D. Cooper, Harry W. Schroeder, Jr. 324. Psöriatik Artrit ve Gastrointestinal Hastalık ile
Didem Arslan, Yahya Sağlıker İlişkili Artritler 2003
309. İnsan Bağışıklık Yetmezliği Virüs (HIV) Hastalığı; Peter H. Schur
Selda Bağış
AİDS ve İlişkili Bozukluklar 1852
Anthony S. Fauci, H. Clifford Lane
325. Tekrariayıcı Polikondritve Diğer Artritler 2005
Mehmet Soy, Ömer Nuri Pamuk
Bruce C. Gilliland
K ISIM 2
Özlem B. Çimen
İM.'-iü'.N HASARLA İL İŞ K İL İ KONUKLUKLAR
326. Ekstremitelerin Periartiküler Hastalıkları 2016
310. Alerjiler, Anafilaksi, ve Sistemik Mastositozis 1913 Bruce C. Gilliland
K. Frank Austen Özlem B. Çimen
 342. Osteoporoz 2226
Robert Lindsay. Felicia Coşman
Musa Bali, Tarkan Karakan

343. Paget Hastalığı ve Kemiğin Diğer Displazileri 2237

Stephen M. Krone. Alan L. Schiller
Yasemin Erten, Bahadır Ercan
327. Endokrinolojinin Prensipleri 2019
J. Larry Jameson
Muştala Araz

328. Ön Hipofiz ve Hipotalamus Hastalıkları 344. Lipoprotein Metabolizması Bozuklukları 2245

2029
Henry N. Ginsberg. Ira J. Goldberg
Shlomo Melmed
Liilüfer Tamer. Bahadır Ercan
Kürşat Özşahin, Yahya Sağlıker
345. Henıokromatozis 2257
329. Nörohipofiz Bozuklukları 2052
Lawrie W. Powell, Kurt J. Isselbacher
Gary L. Robertson
Şükrü Dumlu, Bülent Değertekin
Belda Dursun. Gültckin Süleymanlar
346. Porfirialar 2261
330. Tiroid Bezi Hastalıkları 2060
Robert J. Desnick
J . Larry Jameson, Anthony P. Weetman
Pınar Ergin. Sıddık Momin Adam, Yahya Sağlıker
Mehmet Horoz , Yahya Sağlıker
347. Pürin ve Pirimidin Metabolizma Bozuklukları 2268
331. Adrenal Korteksin Hastalıkları 2084 Robert L. Wortmann
Gordon H. Williams, Robert G. Dlıthy Kuddusi Cengiz, Okay Özer
Meltem Pekpak
348. Wilson Hastalığı 2274
332. Feokromositoma 2105 /. Herbert Seheinberg
Lewis Landsberg. James B. Young Selahattin Ünal
Musa Bali
349. Lizozomal Depo Hastalıkları 2276
333. Diabetes Mellitus 2109 Gregory A. Grabowski
Alvin C. Powers Bülent Değertekin
Mustafa Araz
350. Glikojen Depo Hastalıkları ve Karbonhidrat
334. Hipoglisemi 2138 Metabolizmasının Diğer Kalıtsal Geçişli
Philip E. Cryer Bozuklukları 2281
Binnur Erbağ , Mustafa Araz Yuan-Tsong Chen
Bülent Değertekin
335. Testisin Hastalıkları 2143
James E. Griffin, Jean D. Wilson 351. Konnektif (Bağ) Dokunun Kalıtsal Hastalıkları 2290
İ. Atilla Arıdoğan Darwin J. Prockop, Helena Kuivaniemi, Gerard Tromp.
Leena Ala-Kokko
336. Kadın Üreme Sistemi ve Overiıı Hastalıkları 2154 Nurcan Araş Ateş
Bruec R. Carr. Karen D. Bradshaw
Meral Aban, Aytekin Altıntaş 352. Kalıtsal Aminoasit Metabolizması ve Depo
Hastalıkları 2301
337. Göğüste Endokrin Bozukluklar 2168 Nicola Longo
Jean D. Wilson Nurcan Araş Ateş
Yalçın Kekeç
353. Membran Transportunun Kalıtsal Bozuklukları 2309
338. Cinsel Farklılaşma Bozuklukları 2172 Nicola Longo
Jean D. Wilson, James E. Griffin Nurcan Araş Ateş
Şaban Doran
354. Lipodistrofiler ve Diğer Primer Yağ Doku
339. Multipl Endokrin Sistemleri Etkileyen Hastalıklar 2184 Bozuklukları 2316
Steven /. Sherman, Robert F. Gaged Abhimanyu Garg
Levent Zaman, Sıddık Momiıı Adam, Yahya Sağlıker Tamer C. İnal

Tamer C. İnal, Işıl Öcal

340. Kemik ve Mineral Metabolizmasına Giriş 2192

Michael F. Holick, Stephen M. Krone
Murat Duranay, Serdar Güler

341. Paratiroid Bezinin Hastalıkları ve Diğer Hiper- ve

Hipokalsemik Bozukluklar 2205 355. Hastalıkların Nörobiyolojisi 2321
John T. Potts, Jr. Stephen L. Hauser. M. Flint Beal
Aydan Yüksel, Galip Güz, Nedim Yılmaz Selçuk Yakup Sarıca
356. Nörolojik Hastalıklarda Hastaya Yaklaşım 2326 373. Viral Menenjit ve Ensefalitler 2471
Joseph B. Martin, Stephen L. Hauser Kenneth L, Tyler
Ayşe Filiz Koç, Yakup Sarıca Semiha Gülsüm Kurt

357. Santral ve Periferik Sinir Sistemlerinin 374. Kronik ve Tekrarlayan Menenjit 2481
F.lektrofizyolojik Çalışmaları 2331 Walter J. Koroshetz, Morton N. Swartz
Michael J. Aminoff Ali Özeren
Hacer Bozdemir
375. Prion Hastalıkları 2486
358. Nörolojik Bozukluklarda Nöroradyoloji 2337 Stanley B. Prusiner, Patrick Bosque
William P. Dillon Ejder Küçükaltun, Yahya Sağlıker
Şebnem Bıçakçı
376. Nörolojik Yoğun Bakım 2491
359. Nörolojik Bozuklukların Moleküler Tanısı 2342 J. Claude Hemphill. M. Flint Beal, Daryl R. Gress
Joseph B. Martin, Frank M. Longo Münife Neyal
Şebnem Bıçakçı
K ISIM 1 KISIM 3
SİN İR VK KA SLA RIN BO ZU K LU K LA RI
SANTRAL SİN İR S İS T E M İ H A STA LIK LA R I

360. Nöbetler ve Epilepsi 2354 377. Periferik Nöropatili Hastalara Yaklaşım 2498
Daniel H. Lowenstein Arthur K. Asbury
Hacer Bozdemir Ş. Fatin Reel

361. Serebro Vasküler Hastalıklar 2369 378. Guillain-Barre Sendromu ve Diğer İmmün-Aracılı
Wade S. Smith, Stephen L. Hauser, J. Donald Easton Nöropatiler 2507
Ayşe Filiz Koç, Yakup Sarıca Arthur K. Asbury, Stephen L. Hauser
Ayşe Filiz Koç, Yakup Sarıca
362. Alzheimer Hastalığı ve Diğer Primer Demanslar 2391
Thomas D. Bird 379. Charcot-Marie-Tooth Hastalığı ve Diğer Herediter
Ali Özeren Nöropatiler 2512
363. Parkinson Hastalığı ve Diğer Ekstrapiramidal Sistem Phillip F. Chance, Thomas D. Bird
Hastalıkları 2399 Ayşe Filiz Koç, Yakup Sarıca
Michael J. Aminoff
380. Miyastenia Gravis ve Nöromusküler Kavşağın Diğer
Meltem Demirkıran
Hastalıkları 2515
364. Ataksik Bozukluklar 2406 Daniel B. Drachman
Roger N. Rosenberg Münife Neyal
Meltem Demirkıran
381. Kas Hastalığı olan Hastaya Yaklaşım 2520
365. Amyotrofik Lateral Skleroz ve Diğer Motor Nöron Jerry R. Mendell
Hastalıkları 2412 Münife Neyal
Robert H. Brown, Jr.
382. Polimiyozit, Dermatomiyozit, ve Inklüzyon Cismi
Ş. Fatin Reel
Miyoziti 2524
366. Otonom Sinir Sistemi Bozuklukları 2416 Marinos C. Dalakas, Jr.
John W. Engstrom, Joseph B. Martin Mustafa Yılmaz
M. Betigül Yürüten, Emine Genç
383. Müsküler Distrofiler ve Diğer Müsküler Hastalıklar 2529
367. Kraniyal Sinirlerin Sık Görülen Hastalıkları 2421 Robert H. Brown, Jr., Jerry R. Mendell
M. Flint Beal, Stephen L. Hauser Mustafa Yılmaz
Ümit Hıdır Ulaş KISIM 4
368. Omurilik Hastalıkları 2425 KRONİK YORGUNLUK SKNDUO.MU
Stephen L. Hauser
Süleyman İlhan 384. Kronik Yorgunluk Sendromu 2541
Stephen E. Straus
369. Kafa ve Omurganın Travmatik Yaralanmaları 2434
Lut Tamam, Mehmet Ünal
Allan H. Ropper
Cavit Boz >.İSİM 5
İ’M K -V U 'N io BOZU K LU K LA R
370. Sinir Sisteminin Primer ve Metastatik Tümörleri 2442
Stephen M. Sağar, Mark A. Israel
385. Ruhsal Bozukluklar 2542
Kazım Uygun, İrfan Çiçin
Victor l. Reııs
371. Multipl Skleroz ve Diğer Demiyelinizan Hastalıklar 2452 Lut Tamam, Nurgül Özpoyraz
Stephen L. Hauser, Donald E. Goodkin
KlSSM *:
Hulusi Keçeci ■ ■ . m a k u l a u ü m u i .i g İ

372. Bakteriyel Menenjitler ve Diğer Pürülan

Enfeksiyonlar 2462 386. Bağımlılığın Biyolojisi 2557
Karen L. Roos, Kenneth L. Tyler Robert O. Messing
Yüksel Kablan Lut Tamam, Mehmet Ünal
387. Alkol ve Alkolizm 2561 394. Radyasyon Yaralanmaları 2585
Marc A. Schuckit Stephen M. Hahn, Eli Glatsteiıı
Lut Tamam, Mehmet Ünal Ferdi Tanır

388. Opioid Madde Kötüye Kullanımı ve Bağımlılığı 2567 395. Ağır Metal Zehirlenmesi 2590
Marc A. Schuckit, David S. Segal Howard Hu
Aylin Ertekin Y a z ıc ı, Kemal Yazıcı Ferdi Tanır

389. Kokain ve Diğer Yaygın Olarak Kötüye Kullanılan

Maddeler
Jack H. Mendehon, Nancy K. Mello
Kemal Yazıcı, Aylin Ertekin Yazıcı

390. Nikotin Bağımlılığı

David M. Burns 396. Zehirlenmeler ve İlaç Aşırı Dozları 2595
Fevziye Toros Christopher H. Linden, Michael J. Burns
Yüksel Gökel

397. Sürüngen Sokmalarının ve Deniz Canlılarına

Işıl Öcal Maruziyetin Neden Olduğu Bozukluklar 2616
Robert L. Norris, Paul S. Auerbach
Esra Saatçi, Nafiz Bozdemir

398. Ektoparazit Enfestasyonları, Eklembacaklıların

Işıl Öcal
Isırıkları ve Sokmaları 2622
James H. Maguire, Andrew Spielman
Ersin Akpınar, Nafiz Bozdemir

391. Spesifik Çevresel ve Mesleki Tehlikeler 2579 Işıl Öcal

Howard Hu, Frank E. Speizer
Ferdi Tanır EK LER

392. Boğulma ve Boğulma Tehlikesi 2581 Ek A: Klinik Önemi Olan Laboratuar Değerleri A -l
Jerome H. Modeli
Ek B: Kültür Örneklerinin Alınması ve Taşınması İçin
Ferdi Tanır
Kurallar A -ll
393. Elektrik Yaralanmaları 2583
İNDEKS 1-1
Raphael C. Lee
Ferdi Tanır
 KATKIDA B UL (İNANLAR

Parantez içerisindeki numaralar yazarların yazdığı konuların numa­ PAUL S. AUERBACH, MD

ralarını göstermektedir. Clinical Professor of Surgery, Division of emergency Medicine, Stanford
University School of Medicine, Los Altos [397]

ELIAS ABRÜTYN, MD
K. FRANK AUSTEN, MD
Professor of Medicine and Public Health; Associate Provost and Associate
Theodore Bevier Bayles Professor of Medicine, Harvard Medical School;
Dean for Faculty Affairs, Department of Medicine, Division of Infectious
Director, Inflammation and Allergic Diseases Research Section, Division of
Disease, MCP Hahnemann University School o f Medicine, Philadelphia
Rheumatology, Immunology and allergy, Brigham and Women’s Hospital,
[143, 144]
Boston [310]

JOHN W. ADAMSON, MD
BERNARD M. BABIOR, MD, PhD
Director, Blood Research Institute, Blood Center of Southeastern Wiscon­
sin, Milwaukee [61, 105] Head, Division of Biochemistry, Department of Molecular and Experimen­
tal Medicine, The Scripps Research Institute; Professor and Staff Physician,
Division of Hematology and Oncology, Department of Medicine, Scripps
DAVID A. AHLQUIST, MD
Clinic and research Foundation, La Jolla [107]
Professor of Medicine, Mayo Medical School; Consultant in Gastroentero­
logy, Mayo Clinic and Foundation, Rochester [42]
KAM ALF. BADR, MD
Professor and Chair, Department of Internal Medicine, American university
LEEN A ALA-KOKKO, MD
o f Beirut (Lebanon); Attending Physician, American University of Beirut
Collagen Research Unit, Biocenter Oulu and Department of Medical Bioc­
Medical Center, Beirut, Lebanon [278]
hemistry, university o f Oulu, Finland [351]

DONALD S. BAIM, MD
MUHAMMAD T. AL-LOZI, MBBS
Professor of Medicine, Harvard Medical School; Director, Center for Mini­
Assistant Professor of Neurology, Washington University, St. Louis [101]
mally invasive Therapy, Brigham and Women’s Hospital, Boston [228,245]

M ICHAEL J. AMINOFF, MD
ROBERT L. BARBIERI, MD
Professor of Neurology, university of California San Francisco, San Franc-
Kate Macy Ladd Professor Obstetrics, Gynecology and Reproductive B i­
cisco [22, 357, 363]
ology, Harvard Medical School; Chairman, Department o f Obstetrics and
Gynecology, Brigham and Women’s Hospital, Boston [7]
KENNETH C. ANDERSON, MD
Associate Professor of Medicine, Harvard Medical School; Medical Direc­
TAMAR F. BARLAM, MD
tor, Blood Component Laboratory, Dana-Farber Cancer Institute, Boston
Assistant Professor of Medicine, Harvard Medical School; Senior associate
[114]
Physician, Beth Israel Deaconess Medical Center, Boston; Director, Project
on antibiotic Resistance, Center for Science in the Public Interest, Washing­
ELLIO TT M. ANTMAN, MD
ton, D.C. [19, 150]
Associate Professor o f Medicine, Harvard Medical School; Director, Samu­
el A. Levine Cardiac Unit, Brigham and Women’s Hospital, Boston [243]
KENNETH J. BART, MD, MPH, MSHPM
Director, Graduate School of Public Health, San Diego State University,
FR ED ER IC K R. APPELBAUM , MD
San Diego [122]
member and Director, Clinical Research Division Fred Hutchinson Cancer
Research Center; Professor and Head, Division of Medical Oncology, uni­
versity o f Washington School of Medicine, Seattle [115] M. FLINT BEAL, MD
Anne Parrish Titzel Professor and Chairman o f Neurology, Weill Medical
GORDON L. ARCHER, MD College; Neurologist-in-Chief, New York Presbyterian Hospital, New York
[367,376]
Chairman, Division of Infectious Diseases, Department of Internal Medici­
ne; Professor of Medicine and Microbiology/Immunology, Medical Colle­
ge of Virginia, Campus of Virginia Commonwealth university, Richmond ROBERT S. BENJAMIN, MD
[137] Internist and Professor of Medicine, chairman, Department of Melano-
ma/Sarcoma Medical Oncology; Medical Director, Multidisciplinary Sar­
JA M ES O. ARMITAGE, MD coma Center, The university o f Texas M.D. Anderson Cancer Center, Hous­
Dean, College o f Medicine, and Professor o f Internal Medicine, Section of ton [98]
Oncology/Hematology, University of Nebraska, Omaha [112]
JOHN E. BENNETT, MD
ARTHUR K. ASBURY, MD Head, Clinical Mycology Section, Laboratory of Clinical Investigation, Na­
Van Meter Professor of Neurology Emeritus, University of Pennsylvania tional Institute of Allergy and Infectious Diseases, National Institutes of He­
School o f Medicine, Philadelphia [23, 377, 378] alth, Potomac [200, 201, 202, 203, 204, 205, 206, 207, 208]

JOHN R. ASPLIN, MD EDWARD J. BENZ, JR ., MD

Assistant Professor of Medicine, Section of Nephrology, University of Chi­ Richard and Susan Smith Professor of Medicine, Professor of Pediatrics
cago, Pritzker School of Medicine, Chicago [276, 279] and Pathology, Harvard Medical School; President, Dana-Farber Cancer
institute, Boston [106]
JOHN C. ATHERTON, M RCP
Lecturer, Department of Medicine, Division of Gastroenterology and Insti­ PAUL D. BERK, MD
tute of Infections and Immunity, University of Nottingham, Nottingham, Department of Medicine, Division of Liver Disease, Mount Sinai School of
England [154] Medicine, New York [294]
DAVID R, B IC K E R S , MD Partners Healthcare System, Boston [32, 33, 34, 36, 3 7 ,2 2 4 ,2 2 5 ,2 3 1 ,2 3 2 ,
Carl Truman Nelson Professor and chairman, Department of Dermatology, 236, 237, 238, 239, 243, 244]
Columbia university. New York [60]
IRW IN M. BRAVERM AN, MD
H EN RY J. BIN D ER, MD Professor of dermatology, Yale University School of Medicine, New Haven
Professor of Medicine, Section of f festiv e Diseases, Yale University, New [571
Haven [2X6]
OTIS W. BR A W L EY , MD
THOM AS D. BIRD, MD Assistant director, Office of Special Populations Research, Office of the Di­
Professor of neurology, university o f Washington; Chief of neurology, Ve­ rector, National Cancer Institute, national Institutes of Health, Bethesda
terans Affairs medical Center, Seattle [26, 362, 379] [80]

N E IL R. B L A C K L O W , MD JO E L G. BREM A N , MD, DTPH

Richard M. Haidack Distinguished Professor of Medicine, Molecular Gene­ Deputy Director Division of international Training and Research, Fogarty
tics and Microboiology, university of Massachusetts Medical School, Wor­ international Center, National Institutes of Health, Bethesda [214]
cester [187]
B A R R Y M. B R EN N ER , MD, DSc(Hon), DMSc(Hon)
M ARTIN J . B L A S E R , MD Samuel A, Levine Professor of Medicine, Harvard Medical School; Direc­
Frederick J. King Professor of internal Medicine, Chairman, Department of tor, Renal Division, Brigham and Women4s Hospital, Boston [47, 49, 268,
Medicine, and Professor of Microbiology, New York University School of 269, 270,. 27 1 ,2 7 3 , 274, 275, 277, 278, 281 ]
Medicine, new york [154, 158]
R O B E R T M. BR EN N ER , MD
C L A R A D. B L O O M FIE L D , MD Associate Medical Director, Clinical Research, Amgen Inc., Thousand
Director, The Ohio State University Comprehensive Cancer Center; Deputy Oaks, California [268]
Director, The arthur G. James Cancer Hospital and Richard J. Solove Rese­
arch Institute; William G. Pace 111 Endowed Chair in Cancer Research; Di­ C H A R L E S G. D. BRO O K , MA, MD
rector and Professor, Division of Hematology and Oncology, Department of Emeritus Professor of Pediatric Endocrinology, university College London,
Internal Medicine; College of Medicine and Public Health, '['he Ohio, Sta­ London, UK [8]
te University, Columbus [111]
C L A IR E V. BR O O M E, MD
RICH A RD S. B L U M B E R G , MD Senior Advisor to the Director, Integrated Health Information Systems,
associate Professor of Medicine, Harvard medical School; Chief, division Centers for Disease Control and Prevention, Atlanta [142]
of Gastroenterology, Department o f Medicine, Brigham and Women’s Hos­
pital, boston [287] R O B E R T H. BRO W N , JR ., DPhil, MD
Associate Neurologist, Massachusetts General Hospital; Professor of Ne­
JE A N L . BOLOGNIA, MD urology, Harvard Medical School, Boston [365, 383]
Professor of Dermatology, yale university School of medicine, New Haven
[57] R O B E R T C. BRUNHAM , MD
Professor of Medicine; Director and Medical Director, university of British
G E O R G E J . BO SL, MD Columbia Centre for Disease Control, Vancouver, BC, Canada [133]
Chainnan, Department of Medicine, Memorial Sloan-Kcttering Cancer
Center; Professor of Medicine, Cornell University Medical College, New H. FR A N K LIN BUNN, MD
York [96] Professor of Medicine, Harvard Medical School; Physician, Brigham and
Women’s Hospital, Boston [107, 108]
PATRICK BO SQ U E, MD
Assistant Professor of Neurology, Institute for neurodegencrative Diseases, DAVID M. BURNS, MD
University of California San Francisco, San Francisco 1375] Professor of Medicine, University of California San diego, san Diego [390]

RICH A RD C . BO U C H ER , MD M IC H A E L J . BURNS, MD
William Rand Kenan Professor of Medicine, University of North Carolina Instructor of Medicine, Harvard Medical School; Department of emergency
at Chapel Hill; Director, Cystic Fibrosis/Pulmonary Research & Treatment Medicine, Division of Toxicology, Beth Israel Deaconess Medical Center,
Center, Chapel Hill 1257] Boston [397]

JO A N R . BU TTER TO N , MD
K A R EN D. BRADSHAW, MD
assistant Professor of Medicine, harvard medical School; Assistant in Me­
Associate Professor oTObstetrics ;utd Gynecology, The University ol'Texas
dicine, Infectious Disease Division, Massachusetts General Hospital, Bos­
Southwestern Medical Center, Dallas [52, 336]
ton [131]

HUGH R . BRADY, MD, PhD

JO H N C. BYR D , MD
Professor of Medicine and Therapeutics, University College Dublin; Mater
Director o f Clinical Research, Hematology-Oncology Service, Department
Misericordiac Hospital, Dublin, Ireland [269, 273, 274, 275]
of Medicine, Walter Reed Army Medical Center, Washington, D.C. [ I l l ]

KEN N ETH D. BRANDT, MD ST EP H E N B. C A LD ER W O O D , MD

Professor of Medicine and head, Rheumatology Division, Indiana Univer­ Chief, Division o f Infectious Diseases, Massachusetts General Hospital;
sity School of Medicine; Director, Indiana University Multipurpose Arthri­ Associate Professor of Medicine (Microbiology and Molecular Genetics),
tis and Musculoskeletal Disease Center, Indianapolis [321] Harvard medical School, Boston [131]

E U G E N E BRAUNW ALD, MD, M D(Hon), ScD(Hon) M IC H A E L C A M İL L E R İ, MD

Distinguished Hersey Professor of Medicine; Faculty Dean for Academic Professor of Medicine and Physiology, Mayo Medical School; Consultant
Programs at Brigham and Women’s Hospital and Massachusetts General in Gastroenterology, Physiology and Biophysics, Mayo Clinic and Mayo
Hospital, Harvard Medical School; Vice-President for Academic Programs, Foundation, Rochester [42]
 Katkıda Bulunanlar

GRANT L. CAM PBELL, MD, PhD WILSON S. COLUCCI, MD

Division of Vector-Borne Infectious Diseases, National Center for Infecti­ Professor of Medicine, and Chief, Cardiovascular Medicine, Boston univer­
ous Diseases, Centers for Disease Control and Prevention, Fort Collins sity School of Medicine, Boston [240]
[162, 175]
GERALD A. COLVIN, DO
MARK D. CARLSON, MD Assistant Professor of Medicine and medical Research Scientist, University
t Vice Chair, Department of Medicine, University Hospitals of Cleveland; o f Massachusetts Memorial Medical Center, Worcester [104]
AssociateProfessor of Medicine, Case Western Reserve University School
o f Medicine, Cleveland [21] MAUREEN T. CONNELLY, MD, MPH
%
-t Instructor in Medicine, Harvard Medical School; Harvard Pilgrim Health
l
CHARLES B. CARPENTER, MD Care, Boston [10]
Professor of Medicine, harvard Medical School; Senior Physician, Brigham
and Women’s Hospital, Boston [272] MAX D. COOPER, MD
Professor of Medicine, Pediatrics and Howard Hughes Medical Institute In­
BRUCE R. CARR, MD vestigator, University of Alabama at Birmingham, Birmingham [308]
Professor and Director, Division of Reproductive endocrinology, and Hol­
der, Paul C. MacDonald Distinguished Chair in obstetrics and Gynecology, LAWRENCE COREY, MD
The University of Texas Southwestern Medical Center, Dallas [52, 336] Professor, Medicine and Laboratory Medicine, and head, Virology Divisi­
on, University o f Washington; Head, Program in Infectious Diseases, Fred
AGUSTIN CASTELLANOS, MD Hutchinson Cancer Research Center, Seattle [182, 197]
Professor o f Medicine and Director, clinical Electrophysiology, University
of Miami School of Medicine, miami [39] FELICIA COŞMAN, MD
Associate Professor of Clinical Medicine, Columbia University; Medical
PH ILLIP F. CHANCE, MD Director, Clinical Research Center, Helen Hayes Hospital, West Haverstraw
Professor of Pediatrics and Neurology, university of Washington School of [342]
Medicine; Chief, Division of Genetics and Development, Children’s Hospi­
tal and regional Medical Center, Seattle [379] MARK A. CREAG ER, MD
Associate Professor of Medicine, Harvard Medical School; Director, Vascu­
FEN G Y-YEE CHANG, MD, DSc lar Center, Brigham and Women’s Hospital, Boston [247, 248]
Associate Professor o f Medicine, National Defense Medical Center; Chief,
Division of Infectious Diseases, Tri-Service General Hospital, Taipei, Ta­ PHILIP E. C RYER, MD
iwan [151] Irene E. and Michael M. Karl Professor of Endocrinology and metabolism,
and Director, Division of Endocrinology, Diabetes and Metabolism, Was­
YUAN-TSONG CHEN, MD, PhD hington university School of Medicine, St. Louis [334]
Professor of Pediatrics and Genetics, and Chief, Division of Medical Gene­
tics, Duke University Medical Center, Durham [350] RONALD G. CRYSTAL, MD
Bruce Webster Professor of Medicine, Director, Institute of Genetic Medi­
JOHN S. CHILD, MD cine, and Director, The Arthur and Rochelle Belfer Gene Therapy Care Fa­
Professor of Medicine, university of California, los Angeles; Co-Chief, Car­ cility, Weill Medical College of Cornell University, New York [318]
diology and Co-Director, ahmanson/UCLA Adult Congenital heart Disease
Center, UCLA Medical Center, los Angeles [234] JOHN J. CUSH, MD
Medical Director, arthritis Center, Presbyterian Hospital o f Dallas, Dallas
OLIVIER M. CHOSIDOW, MD [320]
Department of Internal Medicine, Pitie-Salpetribre Hospital, Paris, France
[59] CHARLES A. C ZEISLER , MD, PhD
Professor of Medicine, Harvard Medical School; Director, Sleep Disorders
RAYMOND T. CHUNG, MD and Circadian Medicine, Brigham and Women’s Hospital, Boston [27]
Medical Director, Liver Transplant Program; Director, Liver Service, Gast­
rointestinal Unit, Massachusetts General Hospital; Assistant Professor of MARINOS C. DALAKAS, JR ., MD
Medicine, Harvard Medical School, Boston [299] Chief, Neuromuscular Diseases Section, National Institute of Neurological
Disorders and Stroke, National Institutes of Health, Bethesda [382]
FREDRIC L. COE, MD
Professor of Medicine and Physiology and Director, Clinical Research Tra­ DANIEL F. DANZI, MD
ining Program, university of Chicago Pritzker School of Medicine, Chica­ Professor and Chair, Department o f Emergency Medicine, University of
go [276, 279] Louisville School of Medicine, Floyd Knobs, IN [20]

ALAN S. COHEN, MD ROBERT B. DAROFF, MD

Distinguished Professor of Medicine in Rheumatology, Emeritus, and Con­ Chief of Staff and Senior Vice President for Academic Affairs, University
rad Wesselhoeft Professor of Medicine, emeritus, Boston University Scho­ Hospitals of Cleveland; Professor of Neurology and Assciate Dean, Case
ol of Medicine; Chief of Medicine and Director, emeritus, Thorndike Me­ Western Reserve University School of Medicine, Cleveland [21]
morial Laboratory, Boston City Hospital, Boston [319]
MEHUL T. DATTANI, MD
JE F F R E Y I. COHEN, MD Senior Lecturer/Honoray Consultant in Pediatric Endocrinology, Institute
Head, Medical Virology Section, Laboratory of Clinical Investigation, Na­ of Child Health and Great Ormond Street Children’s Hospital, London, UK
tional institute of Allergy and Infectious Diseases, national Institutes of He­ [ 8]
alth, Bethesda [184, 193]
CHARLES E. DAVIS, MD
FRANCIS S. COLLINS, MD, PhD Professor of Pathology and Medicine, University of California - San Diego
Director, National Human Genome Research Institute, National Institutes School of Medicine; Director emeritus, Microbiology Laboratory, UCSD
of Health, Bethesda [81] Medical Center, San Diego [211]
JOHN DEL VALLE, MD JANICE DUTCHER, MD
Professor of Medicine, Division of Gastroenterology, Department of Medi­ Professor of Medicine, New York Medical College; Associate Director for
cine, University of Michigan School of Medicine. Ann Arbor [285] Clinical Affairs, Our Lady of Mercy Comprehensive Cancer Center, New
york [102]
BRADLEY M. DENKER, MD
Assistant Professor of Medicine, Harvard Medical School; Associate Physi­ JOHANNA DW YER, MD
cian. Brigham and Women’s Hospital, Boston [47] Professor of Medicine and Community Health, Tufts, University School of
Medicine; Professor. Tuffs, University School of Nutrition Science and Po­
DAVID T. DENNIS, MD, MPH licy; Senior Scientist, Jean Mayer USDA Human nutrition Research Center
Chief. Bacterial Zoonoses Branch, Centers for Disease Control and Preven­ at Tufts University, Boston [73]
tion. Fort Collins [162, 175]
VICTOR J. DZAU, MD
ROBERT L. D ERESIEW ICZ, MD Hersey Professor of the Theory and Practice of Physic (Medicine), Harvard
Assistant Professor of Medicine, Harvard Medical School, Boston 1139, Medical school; Chairman, Department of Medicine, and director of Rese­
159] arch, Brigham and Women's Hospital, Boston [247, 248]

ROBERT J. DESNICK, PhD, MD JE F F E R Y S. DIZIECZKOW SKI, MD

Professor and Chairman, Department of Human Genetics, Mount Sinai Assistant Professor, departments of Pathology and Internal Medicine, Way­
School of Medicine, New York [346] ne State University School of Medicine, Detroit [114]

BETTY DIAMOND, MD J . DONALD EASTON, MD

Chief, Division of Rheumatology, Department of Microbiology and Immu­ Professor and Chair. Department of Clinical neurosciences. Brown Univer­
nology, Albert Einstein College of Medicine. New york [307] sity School of Medicine; Neurologist-in-Chief, Rhode Island Hospital, Pro­
vidence [361]

JU LES L. DIENSTAG, MD
DAVID A. EHRMANN, MD
Associate Professor of Medicine, Harvard Medical School; Physician, Mas­
sachusetts General Hospital, Boston [9 1 ,2 9 5 , 296, 297, 301] Associate Professor, Section of Endocrinology, Department of Medicine,
University of Chicago, Chicago [53]

W ILLIAM P. DILLON, MD
JOHN W. ENGSTROM, MD
Professor of Radiology. Neurology and neurosurgery; Chief, Diagnostic
Neuroradiology. University of California San Francisco, San Francisco Associate Professor of Neurology, and Vice Chairman, Department of ne­
[358] urology. University of California San Francisco, San Francisco [16, 366]

CHARLES A. DINARELLO, MD ALAN EPSTEIN, MD

Professor of Medicine. Harvard Medical School, Brigham and Women’s Assistant Professor of Medicine, Brown University School of Medicine,
Providence [289]
Hospital. Boston [331]

ROBERT G. DLUHY, MD ANTHONY S. FAUCI, MD

Professor of medicine, harvard Medical School, Brigham and Women’s Chief, Laboratory of lmmunoregulation; Director, National Institute of Al­
lergy and Infectious Diseases, National Institutes of Health, Bethesda [191,
Hospital, Boston [331]
305, 309. 317]

RAPHAEL DOLIN, MD
MURRAY J. FAVUS, MD
Maxwell Finland Professor of Medicine, and dean for Clinical Programs,
Professor of Medicine, university of Chicago Prit/.ker School of Medicine;
Harvard Medical School. Boston [181, 189. 190]
Director. General Clinical Research Center; Director, Bone Program, Chi­
cago [279]
DANIEL B. DRACHMAN, MD
Professor of Neurology and Neurosciences: Director, Neuromuscular Unit
ROBERT G. FENTON, MD, PhD
The Johns Hopkins University School o f Medicine, Baltimore [380]
Associate Professor of Medicine, University of Maryland Greenebaum
Cancer Center, Baltimore [82]
JE F F R E Y M. DRAZEN, MD
Professor of Medicine, Harvard Medical School; Senior Physician. Brig­
HOWARD L. FIELD S, MD, PhD
ham and Women’s Hospital, Boston [249. 250. 2 5 1,2 6 6 ]
Professor of Neurology and Physiology, University of California San Fran­
cisco, San Francisco [12]
THOMAS D. DUBOSE, JR ., MD
Peter T. Bohan Professor and Chairman, Department of Internal Medicine;
GREGORY A. F IL IC E , MD
Professor of Molecular and Integrative Physiology. University of Kansas
Associate Professor of Medicine, University of Minnesota; Chief, Infecti­
School of Medicine, Kansas City [50]
ous Disease Section, Veterans Affairs Medical Center, Minneapolis [165]

J. STEPHEN DUMLER, MD ROBERT FINBERG, MD

Associate Professor and Associate Director. Division of Medical microbi­
Professor of Medicine, and Chair Department of Medicine, University of
ology. Department of Pathology, The Johns Hopkins Medical Institutions, Massachusetts Medical School, Worcester [85, 136]
Baltimore [177]
JO Y C E D. FINGEROTH, MD
ANDREA E. DUNAIF, MD Assistant Professor of Medcine, Harvard Medical School; Physician, Beth
Associate Professor of Medicine, Director, Center of Excellence in Wo­ Israel Deaconess Medical Center. Boston [ 136]
men’s Health, Harvard Medical school; Chief, Division of Women’s Health
and Senior Physician, Brigham and Women's Hospital, Boston [6] JE F F R E Y S. F L IE R , MD
George C, Reisman Professor of Medicine, Harvard Medical School: Vice-
MARLENE DURAND, MD Chair for Research, and Chief, Division of Endocrinology, Department of
Assistant Professor of Medicine, Harvard Medical School, Boston [30] Medicine. Beth Israel Deaconess Medical Center. Boston [77] ‘
 atkıda Bui imanlar

JUDAH FOLKMAN, MD ROBERT M. GLICKMAN, MD

Surgeon-in-Chief, emeritus, Director, Surgical Research Laboratory, Child­ Professor o f Medicine and dean, New York university School of Medicine,
ren’s Hospital; Andrus Professor of Pediatric Surgery, Professor o f Cell B i­ New York [46]
ology, Department of Surgery, Harvard Medical School, Boston [83]
IRA J . GOLDBERG, MD
SONIA FRIEDMAN, MD Professor o f Medicine, Division of Preventive Medicine and Nutrition, Co­
Instructor in Medicine, Harvard Medical School; Associate Physician in lumbia University College o f Physicians and Surgeons, new York [344]
Medicine, Brigham and Women’s Hospital, Boston [287]
ARY L. GOLDBERGER, MD
W ILLIAM F. FRIEDMAN, MD Associate Professor o f Medicine. Harvard Medical School; Director, Marg-
J.H. Nicholson Professor of Pediatrics (Cardiology); Associate Dean for ret and H.A. Rey Laboratory for Nonlinear Dynamics in Medicine, Beth Is­
Academic Affairs, University of California, Los Angeles School of Medici­ rael Deaconess Medical Center, Boston [226]
ne and UCLA Medical Center, Los Angeles [234]
SAMUEL Z. GOLDHABER, MD
ADRIANE FUGH-BERMAN, MD Associate Professor of Medicine, Harvard Medical School; Director, Veno­
Assistant Clinical Professor, Department of Health Care Sciences, George us Thromboembolism Research Group; Director, Cardiac Center’s Antico- ■
Washington University School of Medicine, Washington, D.C. [11] agulahon Service, Brigham and Women’s Hospital, Boston [261]

ROBERT F. GAGEL, MD DONALD E. GOODKIN, MD

Chairman, Department o f Internal Medicine Specialties, and Chief, Section San Rafael, California [371]
o f Endocrine Neoplasia and Hormonal Disorders, University of Texas M.D.
Anderson Cancer Center, Houston [339] RAJ K. GOYAL, MD
Associate Chief of Staff for Research and Development. VA Medical Cen­
JOHN I. GALLIN, MD ter, Mallinckrodt Professor o f Medicine, Harvard Medical School, West
Director, NIH Warren Grant g. Magnuson Clinical Center; NIH Associate Roxbury [40,284]
Director for Clinical Research; Chief Laboratory of Host Defenses, Nati­
onal Institute o f Alleigy and Infectious Diseases, National Institutes of He­ GREGORY A. GRABOWSKI, MD
alth, Bethesda [64] Professor of Pediatrics; Director, Division and Program in Human Genetics,
Children’s Hospital Research Foundation, Cincinnati [349]
ABHIMANYU GARG» MD
Professor, Department o f Internal Medicine, Center for Human Nutrition, JACOB GREEN, MD
University of Texas Southwestern Medical Center at Dallas; Director, Di­ Associate Professor o f Medicine, Department of Nephrology, Technion Fa­
abetes Clinic, Department o f Veterans Affairs Medical Center, Dallas [354] culty of Medicine, Haifa, Israel [270],

ROBERT H. G ELBER , MD HARRY B. GREENBERG, MD

Clinical Professor o f Medicine and Dermatology, University o f California Senior Associate Dean for Research, Professor o f Medicine, Microbiology
San Francisco, San Anselmo [170] and Immunology, and ACOS for Research VAPAHCS, Stanford University,
Stanford [192]

JE F F R E Y A. GELFAND, MD
NORTON J . GREEN BERGER, MD
Visiting Professor of Medicine, Harvard Medical School; Distinguished
Professor of Medicine, Tufts University School o f Medicine; Attending Professor of Medicine, and senior Associate Dean for Medical Education,
Physician in Infectious Diseases, Massachusetts General Hospital, Boston University of Kansas school of Medicine, Kansas City [302, 303, 304]
[17, 125]
JOHN S. GREENSPAN, BDS, PhD
ANNE A. GERSHON, MD professor and Chair, Department o f Stomatology and Director, Oral AIDS
Center, School of Dentistry; Professor, Department o f Pathology, and Di­
Professor of Pediatrics, and Director of Division o f Pediatric Infectious Di­
rector, AIDS Clinical Research Center, School o f Medicine, University of
seases, Columbia University College o f Physicians and surgeons, New York
California San Francisco, San, Francisco [31]
[1 9 4 ,1 9 5 ,1 9 6 ]

DARYL R. GRESS, MD
MARC GHANY, MD
Associate Professor of Neurology and Neurosurgery; Director, Neurovascu­
Medical Staff Fellow, Liver Diseases Section, Digestive Diseases Branch,
lar Service, University of California San Francisco, San Francisco [376]
National Institute o f Diabetes and Digestive and Kidney Diseases, National
Institutes o f Health, Bethesda [292]
JAM ES E. GRIFFIN, MD
Diana and Richard C. Strauss Professor in Biomedical Research, and Pro­
RAYMOND J . GIBBONS, MD
fessor of Internal Medicine, University of Texas Southwestern Medical
Arthur M. and Glady D. Gray Professor o f Medicine, Mayo Medical Scho­ Center, Dallas [335, 338]
ol, Rochester [227]

W ILLIAM GROSSMAN, MD
BRUCE C. GILLILAND, MD Myer Friedman Distinguished Professor of Medicine, University of Califor­
Professor of Medicine and Laboratory Medicine, University of Washington nia San Francisco; Chief o f Cardiology, university o f California San Fran­
School of Medicine, Seattel [313, 325,326] cisco Medical Center, San Francisco [228]

HENRY N. GINSBERG, MD RASIM GUCALP, MD

Irving Professor of Medicine, Columbia University College o f Physicians Associate Professor of Medicine, Department o f Oncology, Montefiore Me­
Mid Surgeons, New York [344] dical Center, Albert Einstein College of Medicine, New York [102]

I'Ll GLATSTEIN, MD BEVRA HANNAHS HAHN, MD

Vice-Chairman and Clinical Director, Radiation Oncology, University of Professor of Medicine, Chief of Rheumatology, and Vice-Chair, Depart­
!’ -nnsylvania Medical Center, Philadelphia [394] ment of Medicine, university of California, Los Angeles, Los Angeles [311]
S T EP H E N M. HAHN, MD STEV EN M. H O LLA N D , MD
Assistant Professor of Medicine, Department of Radiation Oncology, uni­ Senior Investigator and Head, lmmunoputhogencsis Unit, Clinical Pat­
versity of Pennsylvania Medical Center, Philadelphia [394] hophysiology Section, Laboratory of Host Defenses, National Institute of
Allergy and Infectious Diseases, National Institute of Health, Bethesda [64]
JA N E T E. H A L L , MD
Associate Professor of Medicine, Harvard Medical School; Assistant Chief, KING K. H O L M ES , MD, PhD
Reproductive Endocrine Unit, Massachusetts General Hospital, Boston [54] Professor of medicine, and Director, Center for AIDS and Sexually Trans­
mitted Diseases, University o f Washington; Head. Infectious Diseases, Har-
S C O TT A. H A LP E R IN , MD borview Medical Center, Seattle [132, 133]
Professor of Pediatrics, and Associate Professor of Microbiology and Im­
munology, Dalhousie University; Head, Pediatric Infectious Diseases, RANDALL K. H O L M ES , MD, PhD
IWK-Grace Health Center, Halifax, Nova Scotia, Canada [152] Professor and Chair, Department of Microbiology, University of Colorado
School of Medicine, Denver [141]
C H A R L E S H. H A LSTED , MD
Professor of Internal Medicine, Division of Clinical Nutrition and metabo­ E R IC G. HONIG, MD
lism, university of California-Davis School of Medicine, Davis [74] Professor of Medicine, Emory University School of Medicine, Atlanta
[258]
R O B E R T I. HANDIN, MD
Professor of Medicine, Harvard Medical School; Co-Director. Hematology JA Y H. H O O FN A G LE, MD
Division, and Executive Vice Chairman, Department of Medicine, Brigham Director, Division of Digestive Diseases and nutrition. National Institute of
and Women's Hospital, Boston [62, 116, 117, 118] Diabeles and Digestive and Kidney Diseases, national Institutes of Health.
Bethesda [292]
GAVIN HART, MD, MPH
Director, STD Services, Royal Adelaide Hospital; Clinical Associate Pro­ JONATHAN C . HORTON, MD, PhD
fessor, School of Medicine, Flinders University, Adelaide South Australia, Associate Professor of Ophthalmology, Neurology, and Physiology, Uni­
Australia [164] versity of California San Francisco, San Francisco [28]

W IL L IA M L . H A SL E R , MD LYN HOWARD, MB
Associate Professor of Internal Medicine, Division of Gastroenterology, Professor of Medicine, associate Professor of Pediatrics, and Head-Divisi­
university of Michigan Medical Center, Ann Arbor [41] on of Clinical Nutrition in Department of Medicine, Albany Medical Colle­
ge, Albany [76]
T E R R Y HASSOLD, PhD
Professor, Department of Genetics, Case Western Reserve University and HOWARD HU, MD, DPH
the Center for Human Genetics, University Hospitals of Cleveland, Cleve­ Associate Professor of Occupational Medicine, Harvard School of Public
land [66] Health; Assistant Professor of Medicine, Harvard Medical School; Associ­
ate Physician, Channing Laboratory, Brigham and Women's Hospital, Bos­
ST EP H E N L . H A U SER, MD ton [5 .3 9 1 ,3 9 5 ]
Betty Anker Fife Professor and Chairman, Department of Neurology, uni­
versity of California San Francisco, San Francisco [355,356, 3 6 1,367, 368, G A RY W. H UNNINGHAKE, MD
371 ,3 7 8 ] Professor, Department of Internal Medicine, and Director, Division of Pul­
monary, Critical Care, and Occupational medicine. University of Iowa Col­
BARTON F. HAYNES, MD lege of Medicine, Iowa City [253]
Frederic M. Hanes Professor of Medicine, anil Chair, Department of Medi­
cine, Duke University Medical Center, Durham [305] EDWARD P. IN G EN ITO , MD
Assistant Professor of Medicine, Harvard Medical School; Director, Pulmo­
J . C LA U D E H E M P H IL L III, MD nary Function Laboratory, Brigham and Women’s Hospital, Boston [266]
Assistant Professor of Neurology, university of California San Francisco;
Director, Neurovascular and Neurocritical Care Program, San Francisco ROLAND H. IN G RAM , J R ., MD
General Hospital, san Francisco [376] Martha West Looney Professor Emeritus, Emory university School of Me­
dicine. Atlanta [3 2 ,2 5 8 ,2 6 5 ]
PATRICK H. HENRY, MD
Chairman, Department of Medicine, St John's mercy Medical Center, St.
THOMAS S. INUI, ScM , MD
Louis [63]
President and CEO, The Fetzer Institute, Kalamazoo, Michigan [10]

BA RBA RA L . HERVALDT, MD, MPH

Medical Epidemiologist, Division of Parasitic Diseases, Centers for Dise­ M ARK A. IS R A E L , MD
ase Control Prevention, Atlanta [215] Professor, Departments o f Neurological Surgery and pediatrics. Director,
Preuss Laboratory of Molecular Neuro-Oncology, university of California
San Francisco, San Francisco [370]
MARTIN S. HIRSCH, MD
Professor of Medicine, Harvard Medical School; Director, AIDS Clinical
Research, Massachusetts General Hospital, Boston [185] KURT J . IS S E L B A C H E R , MD
Distinguished Malilinckrodt Professor of Medicine, Harvard Medical Scho­
BERN A RD H IR SC H EL, MD ol; Physician and Director, Massachusetts General Hospital Cancer Center,
associate Professor of Medicine; Head, HIV/AID.S Section, Division of In­ Boston [91, 282, 289, 295, 296, 297, 345]
fectious Diseases, University Hospital, Geneva [171]
RICHARD F. JA C O B S , MD, FA A P
M IC H A E L F. H O L IC K , MD, PhD Horace C. Cube Professor of Pediatrics, University of Arkansas for Medi­
Professor of Medicine, Department of endocrinology. Diabetes and metabo­ cal Sciences; Chief, Pediatric Infectious Diseases, Arkansas Children's
lism, Boston University School of Medicine, Boston [340] Hospital, Little Rock [161]
 Katkıda Bulunanlar

.1. LARRY JAMESON, MD, PhD J. S. KEYSTONE, MD

Irving S. Cutter Professor and Chairman, Department of Medicine, North­ Professor of Medicine, university of Toronto; Centre for Travel and Tropi­
western university Medical School; Physician-in-Chief, Northwestern Me­ cal Medicine, Division of Infectious Disease, Toronto General Hospital, To­
morial Hospital, Chicago [65, 68, 327, 330] ronto, Ontario, Canada [123]

ROBERT T. JENSEN, MD ELLIO TT K IEFF, MD, PhD

Digestive Diseases Branch, National Institute of Diabetes and Digestive albee Professor of Medicine and microbiology and Molecular Genetics,
and Kidney Diseases, National Institutes of Health, Bethesda [93] Harvard medical School, Boston [180]

DONALD R. JOHNS, MD TALMADGE E. KING, JR ., MD

Associate Professor of Neurology and Ophthalmology; Harvard Medical Constance B. Wofsy Distinguished Professor and Vice Chairman, Depart­
School; Director, Division of Neuromuscular Disease, Beth Israel Deaco­ ment of Medicine, University of California San Francisco; Chief, Medical
ness Medical Center, Boston [67] Services, San Francisco General Hospital, san Francisco [259]

BRUCE E. JOHNSON, MD LOUIS V. KIRCHHOFF, MD, MPH

Associate Professor of Medicine, Brigham and Women’s Hospital and Har­ Professor, department of Internal Medicine, University of Iowa; Staff
vard Medical School; Program Director, Lowe Center for Thoracic onco­ Physician, department of Veterans Affairs Medical Center, Iowa City [216]
logy, Dana-Farber Cancer Institute, Boston [100]
JO E L N. KLIN E, MD
MICHAEL JOSEPH, MD Assistant Professor, university of Iowa College of Medicine, Iowa City
Physician, Weber Medical Clinic, Ltd., Olney Illinois [30] [253]

MARK E. JOSEPHSON, MD HOWARD K. KOH, MD, PhD

Professor of Medicine, Harvard medical School; Director of the Harvard Professor of Dermatology, Medicine and Public Health, Boston university
Thorndike Electrophysiology Institute and Arrhythmia Services, Beth Isra­ Schools of Medicine and Public Health; Co-Director, Skin Oncology Prog­
el Deaconess Medical Center, Boston [229, 230] ram, director, Cancer Prevention and Control Center, Boston [86]

EDWARD L. KAPLAN, MD ANTHONY L. KOMAROFF, MD

Professor of Pediatrics, Department o f Pediatrics, university of Minnesota Professor of Medicine, Harvard medical School; Senior Physician, Briham
Medical school, Minneapolis [235] and Women’s Hospital, Boston [6]

MARSHALL M. KAPLAN, MD PETER KOPP,M D

Professor of Medicine, Tufts University School of Medicine; Chief, Gastro­ Assistant Professor of Medicine, Division of Endocrinology, Metabolism
enterology Department, New England medical Center, Boston [45, 293] and Molecular Medicine, Northwestern University, Chicago [65]

ADOLF W. KARCHMER, MD WALTER J. KOROSHETZ, MD

chief, Division of Infectious Diseases, Beth Israel Deaconess Medical Cen­ Associate Professor of Neurology and Medicine; Associate Director, Stro­
ter; Professor of Medicine, Harvard medical school, Boston [126] ke and Clinical Neurology Services, Massachusetts General Hospital, har­
vard Medical School, Boston [374]

DENNIS L. KASPER, MD, MA (Hon)

P. E. KOZARSKY, MD
William Ellery Channing Professor of Medicine, Professor of Microbiology
Associate Professor of Medicine, Emory university School of Medicine;
and Molecular Genetics, Executive Dean for Academic Programs, Harvard
Adjunct Assistant Professor of Medicine, Emory University School of Me­
medical school; Director, channing Laboratory, Department of Medicine,
dicine; Adjunct Assistant Professor of Medicine, Emory University School
Brigham and Women’s Hospital, Boston [19, 119, 130, 145, 150, 160, 167]
of Public Health, Atlanta [123]

LLO YD H. KASPER, MD
BARNETT S. KRAM ER, MD, MPH
Professor of Medicine (Neurology) and microbiology, Dartmouth Medical
Director, Office of Medical Applications of Research, National Institutes of
School, Hanover [217]
Health, Bethesda [80]

MARK A. KAY, MD, PhD STEPHEN M. KRANE, MD

Director, Program in Human Gene Therapy, and Associate Professor, De­ Persis, Cyrus and Marlow B. Harrison Professor of Medicine, Harvard Me­
partments of Pediatrics and Genetics, Stanford University School of Medi­ dical School; Physician and Chief, Arthritis Unit, Massachusetts General
cine, Stanford [69] Hospital, Boston [340, 343]

ELAINE T. KAYE, MD HELENA KUIVANIEMI, MD, PhD

Clinical Instructor in Dermatology, Harvard Medical School; Assistant in Associate Professor, Wayne State University School of Medicine, Detroit
Medicine, Department of Medicine, Children’s Hospital Medical Center, [351]
Weston [18]
LOREN LAINE, MD
KENNETH M. KAYE, MD Professor of Medicine, university of Sofuthem California School of Medi­
Assistant Professor of Medicine, Harvard Medical school; Associate Physi­ cine, Los Angeles [44]
cian, Division of infectious diseases, Brigham and Women’s Hospital, Bos­
ton [18] ANIL K. LALWANI, MD
Associate Professor, Department of Otolaryngology-Head and Neck Sur­
GERALD T. KEUSCH, MD gery, University of California San Francisco, San Francisco [29]
Associate Director for International research; Director, Fogarty internati­
onal Center, National institutes of Health; Professor of Medicine, Tufts Uni­ LEW IS LANDSBERG, MD
versity School of Medicine; New England Medical Center, Bethesda [122, Professor of Medicine, Vice-President for Medical Affairs, and Dean,
157, 159] Northwestern University Medical School, Chicago [72, 332]
H. CLIFFORD LANE, MD DANIEL H. LOW ENSTEIN, MD
Head, Clinical and molecular Retrovirology Section. Laboratory of lmmu- Carl W. Walter Professor of neurology and dean for Medical Education,
noregulation; Clinical Director, National Institute of allergy and Infectious Harvard Medical School, Boston [360]
Diseases, National Institutes of Health, Bethesda [309]
SHEILA A. LUKEHART, PhD
THOMAS J . LAW LEY, MD Research Professor of Medicine, Division of Allergy and Infectious Dise­
Professor, Department of Dermatology, and Dean, Emory University Scho­ ases, university of Washington School of Medicine, Seattle [172, 173]
ol of Medicine, Atlanta [55, 56, 58]
M. MONIR MADKOUR, DM
RAPHAEL C. L E E , MB M E, MD, ScD, PhD (Hon) Military Hospital, Riyadh, Saudi Arabia; Faculty of Medicine, Ain Shams
university, Cairo, Egypt, Riyadh, Saudi Arabia [160]
Professor of Surgery (Plastic), Professor of Organisma Biology and Ana­
tomy (Biomechanics) and, Director, Electrical Injury Research Program,
university of Chicago; Attending Surgeon, Ancilla / St. Mary’s Bum Cen­ LAW RENCE C. MADOFF, MD
ter, Chicago [393] Assistant Professor of Medicine, Harvard Medical School; Associate Physi­
cian, Channing Laboratory and Division of Infectious Diseases, Brigham
and Women’s Hospital, Boston [119, 127]
THOMAS H. L E E , MD, MSc
Associate Professor, harvard medical school; Medical director, partners
JAM ES H. MAGUIRE, MD
Community Health Care, lnc„ Boston [13]
Associate Professor of Medicine, Harvard Medical School; department of
Immunology and Infectious Diseases, Harvard School of Public Health,
CAMMIE F. LESSER, MD, PhD Boston [129, 3 2 3 ,3 9 8 ]
Infectious Disease Fellow, University of Washington, Seattle [156]

ADEL A.F. MAHMOUD, MD, PhD

MATTHEW E. LEVISON, MD President, Merck Vaccines, Merck & Co., Inc., Whitehouse Station, New
Professor of Medicine and public Health, and Chief, Division of Infectious Jersey [222]
Diseases, Allegheny University of the Health Sciences, Philadelphia [255]
RONALD V. M AIER, MD
PET ER LIBBY, MD Professor and Vice Chairman of Surgery, university öf Washington; Surge­
Mallinckrodt Professor of Medicine, Harvard Medical School; Chief, Car­ on in Chief, Harboriew Medical Center, Seattle [38]
diovascular Medicine, Brigham and Women’s Hospital, Boston [241, 242]
MARK E. M AILLIARD, MD
RICHARD W. LIGHT, MD Associate Professor of Medicine, Division o f Gastroenterology and Hepa­
Professor of medicine, Vanderbilt university; Director, Pulmonary Diseases, tology, university of Nebraska Medical Center, Omaha [298]
Saint Thomas Hospital, Nashville [262]
DANIEL B. M ARK, MD, MPH
Professor o f Medicine, Duke University Medical Center, Director, Outco­
CHRISTOPHER H. LINDEN, MD
mes Research and Assessment Group, Durham [3, 4]
associate Professor, Department of Emergency Medicine, University of
Massachusetts Medical School, Worcester [396]
THOMAS M ARRIE, MD
Professor and Chair, Department of Medicine, university of Alberta, Ed­
ROBERT LINDSAY, MBChB, PhD
monton, alberta, Canada [177]
Professor of Clinical Medicine, Columbia University College of Physicians
and Surgeons; Chief, Internal medicine, Helen Hayes Hospital, West Ha-
JOSEPH B. MARTIN, MD, PhD, MA (Hon)
verstraw, New Şork [342]
Dean of the Faculty of Medicine; Caroline Shields Walker Professor of Ne­
urobiology and Clinical Neuroscience, Harvard Medical School, Boston
MARC E. LIPPMAN, MD
[12, 356, 359, 366]
John G. Searle Professor and chairman, Department of Internal Medicine,
University of Michigan Health Science System, Ann Arbor [89]
JANET R. M AURER, MD
Head, Section of Advanced Lung Disease and Lung Transplantation, Divi­
P ET E R E . LIPSKY, MD
sion of Pulmonary and Critical Care Medicine, and Medical Director,
Scientific Director, National Institute of Arthritis and Musculoskeletal and Transplant Center, The Cleveland Clinic Foundation, Cleveland [267]
Skin Diseases, National Institutes of Health, Bethesda [307, 312, 315, 320]

ROBERT J. M AYER, MD
LEO X. LIU, MD, DTMH
Professor of Medicine, Harvard Medical School; Vice-Chair for Academic
Assistant Professor of Medicine, Harvard Medical School; Division of In­
Affairs, Department of Adult Oncology, Dana-Farber Cancer Institute, Bos­
fectious Diseases, Department of Medicine, Beth Israel deaconess Medical
ton [90, 92]
Center, Boston [219]

BERNARD LO, MD JOHN D. M CCONNELL, MD

Professor of Medicine and Director, Program in Medical Ethics, university Professor of Medicine, Harvard Medical School; Vice-Chair for Academic
of California San Francisco, San Francisco [2] Affairs, Department of Adult Oncology, Dana-Farber Cancer Institute, Bos­
ton [90, 92]

DAN L. LONGO, MD
Scientific Director, National institute on Aging, National institutes of He­ W ILLIAM M. M CCORMACK, MD
alth, Bethesda and baltimofe [6 1 ,6 3 , 79, 82, 84, 103, 112, 113, 191] Professor of Medicine and o f Obstetrics and Gynecology, and Chief, Divi­
sion of Infectious Diseases, State University of New York, New York [178]
FRANK M. LONGO, MD, PhD
Professor of neurology, university of California San Francisco; Chief of Ne­ E. REGIS MCFADDEN, JR ,, MD
urology Veterans Affairs Medical Center, Department of Neurology, San Argyl J. Beams Professor of Medicine, Director, Division of Pulmonary and
Francisco [359] Critical Care Medicine, University Hospitals of Cleveland, Cleveland [252]
KEVIN T, MCVARY, MD ROBERT S. MUNFORD, MD
Associate Professor, Department of Urology, Northwestern university Me­ Jan and Henri Bromberg Professor of Internal Medicine, and Professor of
dical School, Chicago [51] Microbiology, university o f Texas Southwestern Medical Center, Dallas
[124, 146]
NANCY K. M ELLO, PhD
Professor of Psychology (Neuroscience), harvard Medical School; Alcohol TIMOTHY F. MURPHY, MD
and Drug Abuse Research Center, McLean Hospital, Belmont [389] Professor of Medicine and Microbiology, and Chief, Division of Infectious
Diseases, State University of New York at Buffalo, Buffalo [149]
SHLOMO MELMED, MD
Professor and Director, Cedars Sinai Research Institute, University of Cali­ DANIEL M. MUSHER, MD
fornia Los Angeles School of Medicine, Los Angeles [328] Professor of Medicine, and Professor of Molecular Virology, Baylor Colle­
ge of Medicine; Chief, Infectious Diseases, Veterans Affairs Medical Cen­
JE R R Y R. MENDELL, MD ter, Houstan [138, 148]
Chairman and Professor of Neurology; Director, Neuromuscular Disease
Center, The ohio State University, Columbus [381,383] ROBERT J , M YERBURG, MD
Professor o f Medicine and Physiology; Director, Division of Cardiology,
JA C K H. MENDELSON, MD university of Miami School of Medicine, Miami [39]
Professor of Psychiatry (Neuroscience), Harvard Medical School; Alcohol
and Drug Abuse Research Center, McLean Hospital, Belmont [389] GERALD T. NEPOM, MD, PhD
Professor, Department o f Immunology, University of Washington School of
ROBERT O. MESSING, MD Medicine; Director, Virginia Mason Research Center, Seattle [306]
Associate Professor of Neurology, and Associate Director, Ernest Gallo Cli­
nic and Research Center, university o f California San Francisco, San Fran­ RICHARD A. NISHIMURA, MD
cisco [386] Professor o f Medicine, Mayo Medical School, Rochester [227]

M. -MARSEL MESULAM, MD ROBERT L. NORRIS, MD

Ruth and Evelyn Dunbar Professor o f neurology and Psychiatry; Director, Associate Professor o f Surgery, Department of Surgery; Chief, Division of
Center for Behavioral and Cognitive Neurology; Director, Alzheimer’s Emergency Medicine, Stanford university, Stanford [379]
Program, Northwestern University Medical school, Chicago [25]

THOMAS B. NUTMAN, MD
SUSAN MIESFELDT, MD
Head, Helminth Immunology Section, Laboratory of Parasitic Diseases,
Assistant Professor of Medicine, Division of Hematology and Oncology,
National Institute of Allergy and Infectious Diseases, National Institutes of
University of Virginia Health System, Charlottesville [68]
Health, Bethesda [220,221]

EDGAR L. MILFORD, MD
JOHN A. OATES, MD
Associate Professor of Medicine, Harvard Medical School; Director of Re­
The Thomas F. Frist, Sr. Professor of Medicine, and Professor o f Pharma­
nal Transplantation, Brigham and Women’s Hospital, Boston [272]
cology, Vanderbilt University School of Medicine, Nashville [70]

SAMUEL I. M ILLER, MD
Professor of Medicine and Microbiology, University of Washington, Seatt­ RICHARD J . O’BREIN, MD
le [156] Chief, Research and Evaluation Branch Division of Tuberculosis Elimina­
tion, Centers for Diseases Control and Prevention, atlanta [169]
JOHN D. MINNA, MD
Professor, internal Medicine and Pharmacology; Director, Hamon Center PATRICK T. O’GARA, MD
for Therapeutic Oncology Research, University of Texas Southwestern Me­ Associate Professor of Medicine, Harvard Medical School; Director, Clini­
dical Center, Dallas [88] cal Cardiology, Brigham & Women’s Hospital, Boston [34]

JER O M E H. MODELL, MD CHRISTOPHER A. OHL, MD

Associate Vice President for Health Affairs, and Professor of Anesthesi­ Assistant Professor of Medicine, Section on Infectious Diseases, Wake Fo­
ology, College of Medicine, university of Florida, Gainesville [392] rest University School of Medicine; Director, Center for Antimicrobial Uti­
lization, Stewardship and Epidemiology, Baptist Medical Center, Winston-
THOMAS A. MOORE, MD Salem [155]
Clinical Assistant Professor, Department of Internal Medicine, university of
Kansas School of Medicine, Wichita [212] RICHARD K. OLNEY, MD
Professor of Neurology, university of California San Francisco, San Fran­
MARC MOSS, MD cisco [22]
Assistant Professor of Medicine, Emory University School of Medicine;
Director, Medical Intensive Care Unit, Grady Memorial Hospital, Atlanta
YVONNE M. O’MEARA, MD, FR CPI
[265]
Senior Lecturer in Medicine, University College Dublin; Consultant Neph­
rologist, Mater Misericordiae Hospital, Dublin, Ireland [274, 275]
ROBERT J . MOTZER, MD
Associate Attending Physician, Division of Solid Tumor Oncology, Depart­
ment of Medicine, Memorial Sloan-Kettering Cancer Center; Associate ANDREW B. ONDERDONK, PhD
Professor of Medicine, Cornell University Medical College, New York [94, Professor of Pathology, Harvard Medical School; Director of Clinical Mic­
96] robiology, Brigham and Women’s Hospital, Boston [121]

HARALAMPOS M. MOUTSOPOULOS, MD ROBERT A. O’ROURKE, MD

Professor and Director, Department o f Pathophysiology, National Univer­ Charles Conrad Brown Distinguished Professor of Cardiovascular Science,
sity School of Medicine; President of the National Organization for Medi- University of Texas Health Science Center at San Antonio, San Antonio
l ines, Athens, Greece [314, 316] [225]
CHUNG OW YANG, MD Vanderbilt University School of Medicine; Chief, Section of endocrinology
Professor of Internal Medicine, H. Marvin Pollard Collegiate Professor and and Diabetes, VA Medical Center, Mashville [333]
Chief, Division of Gastroenterology, Department of Internal Medicine, Uni­
versity of Michigan Medical Center, Ann Arbor [288J D A N IEL S. PRA TT, MD
Assistant Professor of Medicine, Tufts University School of Medicine; Me­
J E F F R E Y PARSONNET, MD dical Director of Liver Transplantation, New England Medical Center, Bos­
Associate Professor of Medicine and of Microbiology, Dartmouth Medical ton [45, 293]
School: Staff Physician, Infectious Diseases Section, Dartmouth-Hitchcock
Medical Center, Lebanon [139] DARW IN J . PR O C K O P, MD, PhD
Professor and Director, Center for Gene Therapy, Philadelphia [351]
SH REYA SK U M A R R . P A T E L , MD
Associate Professor of Medicine, Department of Melanoma/Sarcoma, Me­ D A N IEL T. P R IC E , MD
dical Oncology, University of Texas, MD Anderson Cancer Center, Hous­ Assistant Professor of Medicine, Boston University School of Medicine;
ton [98] Staff Physician, Boston Veterans Affairs Medical Center, West roxbury
[240]
GUSTAV PAU M G A RTN ER, MD
Professor of Medicine, Ludwig Maximilian! University of Munich, Durch- STA N LEY B. PR U SIN ER , MD
wal, Germany [302] Director, Institute for Neurodegenerative Diseases; Professor, Departments,
of Neurology, Biochemistry and Biophysics, University of California San
S T EPH EN J . P E R O U T K A , MD Francisco, San Francisco [375]
Burlingame, California [15]
P E T E R J . Q U E S E N B E R R Y , MD
M IC H A E L C. P E R R Y , MD, MS Professor of Medicine, university of Massachusetts School of Medicine,
Professor of Internal Medicine; Director, Division of Hematology/Onco- Worcester [ 104]
logy, Nellie B. Smith Professor of Oncology, University of Missouri/Ellis
Fischel Cancer Center: Consultant, Harry S. Truman VA Hospital, Colum­ SANJAY RA M , MD
bia [103] Assistant Professor of Medicine, Section of Infectious Diseases, Boston
University School of Medicine and Boston Medical Center, Boston [147]
ALAN PESTR O N K , MD
Professor of Neurology, Washington University, St. Louis [101] DID IER RAOULT, MD
Professor of Medicine, Unite des Rickettsies, School of Medicine, Univer­
C L A R E N C E J . P E T E R S , MD sity of Aux-Marseille, Marseille, France [177]
Chief. Special Pathogens Branch, Centers for Disease Control and Preven­
tion; Adjunct Professor of Microbiology and Immunology, Emory Univer­ N E IL H. RA SKIN , MD
sity, Atlanta [198, 199] Professor of Neurology, university of California San Francisco, San Fran­
cisco [15]
E L IO T A. P H ILLIPSO N , MD
Sir John and Lady Eaton Professor and chair. Department of Medicine, Uni­ M ARIO RA V IG LIO N E, MD
versity of Toronto, Toronto, Ontario, Canada [263, 264] TB Coordinator, Communicable Disease Programme, World Health Orga­
nization, Geneva, Switzerland [169]
G E R A LD B. P IE R , PhD
Professor of Medicine (Microbiology and Molecular Genetics), Harvard SHARON L . R E E D , MD
Medical School; Microbiologist, Brigham and Women's Hospital, Boston Professor of Pathology and Medicine, and Director, Microbiology and Vi­
[ 120] rology Laboratories, University of California, San Diego Medical Center,
San Diego [2 13]
D A N IEL K. PO D O LSK Y, MD
Mallinckrodt Professor of Medicine, Harvard Medical School; Chief of
ANTONIA J . REG IN A TO , MD
Gastrointestinal unit; Director, Center for the Study of Inflammatory Bowel
Professor of Medicine, and Head. Division of Rheumatology, Cooper Uni­
Disease, Massachusetts General Hospital, Boston [282, 299, 300]
versity Medical Center, Robert Wood Johnson Medical School at Camden,
Camden [322]
RONALD E . P O L K , P harm . D.
Professor, Pharmacy and medicine. School o f Pharmacy Medical College of
RICH A RD C. REIC H M A N , MD
Virginia Campus, Virginia Commonwealth University, Richmond [137]
Professor of Medicine, Microbiology and Immunology, Head Infectious Di­
seases Unit, Senior Associate Dean for Clinical Research, University of
M A TTH EW P O L L A C K , MD
Rochester School of Medicine and Dentistry, Rochester [188]
Professor of Medicine, Uniformed Services University; F. Edward He’bert
School of Medicine; Attending Staff Physician, Internal Medicine and In­
fectious Diseases, National Naval Medical Center. Bethesda [155] C A R O L M. R E IF E , MD
Clinical Assistant Professor of Medicine, Jefferson Medical College, Tho­
JO H N T. PO TTS, JR ., MD mas Jefferson University, Philadelphia [43]
Distinguished Jackson Professor of Clinical Medicine, Harvard Medical
School; Director of Research, Massachusetts General Hospital, Boston JO H N T. R E P K E , MD
[341] Chris J. and Marie A. Olson Professor of Obstetrics and Gynecology, and
Chainnan, Department of Obstetrics and Gynecology. University of Neb­
L A W R IE W. P O W E L L , MD, PhD raska Medical Center, Omaha [7]
Professor of Medicine, The university of Queensland and Royal Brisbane
Hospital, Brisbane, Queensland, Australia [345] N E IL M. R E S N IC K , MD
Professor of Medicine, University of Pittsburgh School of Medicine; Chief,
ALVIN C. P O W ER S, MD Division of Gerontology and Geriatric Medicine, University of Pittsburgh
Associate Professor of Medicine, Molecular Physiology and Biophysics, Healthcare System, Pittsburgh [9]
 Katkıda Bulunanlar

VICTOR I. REUS, MD I. HERBERT SCHEINBERG, MD

Professor of Psychiatry, University o f California San Francisco; Medical Senior Lecturer in Medicine, College of Physicians and surgeons, Colum­
Director, langley Porter Hospital, San Francisco [385] bia University, New York [348]

PETER A. RICE, MD HOWARD I. SCHER, MD

Professor of Medicine and Chief, Section of Infectious Diseases, Boston Attending Physician, Chief, Genitourinary Oncology Service, Division of
University School of Medicine and Boston Medical Center, Boston [147] Solid Tumor Oncology, Department of Medicine, Memorial Sloan-Kette-
ring Cancer Center; Professor of Medicine, Department of Medicine, Weill
STUART RICH, MD Medical College, New York [94, 95]
Professor of Medicine, Rush Medical College; Director, Rush Heart Insti­
tute Center for Pulmonary Heart Disease, Chicago [260] ALAN L. SCH ILLER, MD
Irene Heinz Given and John LaPorte Given Professor and Chairman of Pat­
GARY S. RICHARDSON, MD hology, Mount Sinai School of Medicine; Chairman of Pathology, The Mo­
Assistant Professor of Psychiatry, Case Western Reserve University; Seni­ unt Sinai Hospital, New York [343]
or Research Scientist, Sleep Disorders and Research Center, Henry Ford
Hospital, Cleveland [27] HARRY W. SCHROEDER, JR ., MD, PhD
Professor of Medicine and Microbiology, University o f Alabama at Bir­
C E L E ST E ROBB-NICHOLSON, MD mingham, Birmingham [308]
Assistant Professor of Medicine, Harvard Medical School; Assistant Physi­
cian, Massachusetts General Hospital, Boston [6] JOHN S. SCHROEDER, MD
Professor of Medicine, Cardiovascular Medicine, Stanford University
GARY L. ROBERTSON, MD School of Medicine, Stanford [233]
Professor of Medicine and Neurology, Northwestern University Medical
School, Chicago [329] ANNE SCHUCHAT, MD
Chief, Respiratory Diseases Branch, Division of Bacterial and Mycotic Di­
DAN M. RODEN, MD seases, National Center for Infectious Diseases, Centers for Disease Cont­
Professor of Medicine and Pharmacology; Director, Division of Clinical rol and Prevention, Atlanta [142]
Pharmacology, Vanderbilt University School of Medicine, Nashville [70]
MARC A. SCHUCKIT, MD
KAREN L. ROOS, MD Professor of Psychiatry, University of California San Diego, and Veterans
Professor of Neurology, Indiana University School of Medicine, Indianapo­ Affairs Medical Center, San Diego [387, 388]
lis [372]
PETER H. SCHUR, MD
ALLAN H. ROPPER, MD
Professor of Medicine, Harvard Medical School; Physician, Brigham and
Professor and Chairman of Neurology, Tufts University School of Medici­
Women’s Hospital, Boston [324]
ne; Chief, Division of Neurology. St. Elizabeth’s Medical Center, Boston
[24, 369]
STUART SCHWARTZ, PhD
ROGER N. ROSENBERG, MD Professor, Department of Genetics, Case Western Reserve University and
Zale Distinguished Chair in Neurology; Professor of Neurology and Physi­ the Center for Human Genetics, University Hospitals of Cleveland, Cleve­
ology, University of Texas Southwestern Medical Center; Attending Neuro­ land [66]
logist, Parkland Hospital and Zale-Lipsky University Hospital, Dallas [364]
DAVID S. SEGAL, PhD
W ENDELL ROSSE, MD Professor of Psychiatry, university o f California San Diego, La Jolla [388]
Florence Reynaud McAlister Professor of Medicine and Medical Research,
Department of Medicine, Duke University Medical School, Durham [108] JULIAN L. SEIFTER , MD
Associate Professor o f Medicine, Harvard Medical School; Physician, Brig­
DAVID W. RUSSELL, MD, PhD
ham and Women’s Hospital, Boston [281]
Associate Professor of Medicine, Division of Hematology University of
Washington School of Medicine, Seattle [69]
ANDREW P. SELW YN, MA, MD
ROBERT M. RUSSELL, MD Professor of Medicine, Harvard medical School, Boston [244]
Professor of Medicine and Nutrition, Tufts University; Associate Director,
USDA Human Nutrition Research Center, Tufts University, Boston [75] STEVEN I. SHERMAN, MD
Associate Professor, Section of Endocrine Neoplasia and Hormonal Disor­
THOMAS A. RUSSO, MD, CM ders, university of Texas M.D. Anderson Cancer Center, Houston [339]
Assistant Professor of Medicine, Division of Infectious Diseases, Depart­
ment of Medicine, State University of New York at Buffalo, Buffalo [153, KARL SKORECKI, MD
166]
Annie Chutick Professor of Medicine, Bruce Rapport Faculty of Medicine,
Technion-Israel Institute of Technology; Director, Department of Nephro­
STEPHEN M. SAGAR, MD
logy and Molecular Medicine, Rambam Medical Center, Haifa, Israel [270]
Professor of Neurology, Case Western Reserve School of Medicine, Cleve­
land [370]
W ILLIAM SİLEN, MD
EDWARD A. SAUSVILLE, MD, PhD Johnson and Johnson Distinguished Professor of Surgery, and dean for Fa­
Associate Director, Developmental Therapeutics Program, Division of Can­ culty Development and diversity, Harvard medical School; Physician, Brig­
cer Treatment and Diagnosis, National Cancer Institute, Bethesda [84] ham and Women’s Hospital, boston [14, 290, 291]

MOHAMED H. SAYEGH, MD GARY G. SINGER, MD

Associate Professor of Medicine, Harvard Medical School; Research Direc­ Assistant Professor of Medicine, Washington University School of Medici­
tor, Laboratory of lmmunogenetics and Transplantation, Brigham and Wo­ ne; Associate Director, Transplant Nephrology, Barnes Jewis Hospital, St.
men’s Hospital, Boston [272] Louis [49]
AJAY K. SINGH, MD MORTON N. SWARTZ, MD
Associate Professor of Medicine, Harvard Medical School; Directory of Professor, Department of Medicine, Harvard Medical School; Chief, James
Clinical Nephrology, Brigham and Women’s Hospital, Boston [271] Jackson Firm Medical services, Massachusetts General Hospital, Boston
[3741
JEAN D. SIPE, PhD
Scientific Review Administrator, Center for Scientific Review, National ROBERT A. SW ER LIC K , MD
Institutes of Health; Adjunct Professor, Department o f Biochemistry, Bos­ Associate Professor, Department of dermatology, Emory University School
ton University School of Medicine, Bethesda [319] o f Medicine, Atlanta [56]

WADE S. SMITH, MD, PhD A.JAM IL TAJIK, MD

Assistant Professor of Neurology; Director, Stroke Service, university of Thomas J. Walker Jr. Professor of Medicine and Pediatrics, Mayo Medical
California San Francisco, San Francisco [361] School; Chair, Division of Cardiovascular Diseases, Mayo Clinic, Roches­
ter [227]

JAM ES B. SNOW, JR ., MD
Professor Emeritus, department of Otorhinolaryngology, University of JO E L D. TAUROG, MD
Pennsylvania; former Director, national Institute on Deafness and Other Professor of Internal Medicine, and William M. and Gay Burnett Professor
Communication Disorders, National Institutes of Health, Bethesda [29] for Arthritis Research, University of Texas Southwestern Medical Center;
Interim Chief, Division of Rheumatic Diseases and Interim Director, Ha­
rold C. Simmons Arthritis Research Center, Dallas [306, 315]
ARTHUR J. SOBER, MD
Associate Professor of Dermatology, Harvard Medical School; Associate
SCOTT J . TH ALER, MD
Chief of Dermatology, Massachusetts General Hospital, Boston [86]
Director, Clinical Monitor, Clinical Research, Vaccines, Merck Research
Laboratories. Merck & Co., Inc., Blue Bell [323]
M ICHAEL F. SO RRELL, MD