mecanismo de accion del fluconazole pdf

Mechanism of fluconazole resistance in Candida krusei. Results: The resistance mechanisms to fluconazole expressed by Candida glabrata are mainly determined by the upregulation of Adenosine triphosphate Binding Cassette ABC pumps and by the modification of the point of attachment with its pharmacological target: the enzyme lanosterol alpha-demethylase. Lanosterol 14 alpha-demethylase PDM : effects of PDM inhibitors on sterol biosynthesis downstream of lanosterol. Pharmacokinetics of sequential intravenous and enteral fluconazole in critically ill surgical patients with invasive mycoses and compromised gastro-intestinal function. Clin Microbiol Rev ;

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