Quarto, R. Javazon, E. During the reproduction period, antlers cease to grow and the skin covering them velvet is shed. We have been able to identify specific parameters that are crucial for an efficient and easily reproducible differentiation of human ASCs into ECs and SMCs within 14 days of in vitro culture. However, the translation from small animal models, through large animal models, to humans has proven to be difficult and the optimal dose of growth factors for human clinical therapy is difficult to determine, because of the large variation of efficacy between small to big animals up to fold.
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